Expression of wild-type human superoxide dismutase-1 in mice causes amyotrophic lateral sclerosis

KS Graffmo, K Forsberg, J Bergh, A Birve… - Human molecular …, 2013 - academic.oup.com
superoxide dismutase-1 were found in spinal cords, but also in the brain. The findings show
that wild-type human superoxide dismutase-1 has … of the protein in the disease in humans. …

… expressing human cytosolic copper–zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease

M Nagai, M Aoki, I Miyoshi, M Kato… - Journal of …, 2001 - Soc Neuroscience
… copper–zinc superoxide dismutase (SOD1). We report here that rats that express a human
SOD1 … As in the human disease and transgenic ALS mice, pathological analysis demonstrates …

Superoxide dismutase expression in human cumulus oophorus cells

L Matos, D Stevenson, F Gomes… - Molecular human …, 2009 - academic.oup.com
… It is hypothesized that superoxide dismutase (SOD), a first line antioxidant enzyme, is
associated with oocyte quality. Cells obtained in the course of ART for the treatment of infertility …

Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential

I Batinić-Haberle, JS Rebouças… - Antioxidants & redox …, 2010 - liebertpub.com
… as an underlying condition in a number of diseases, such as ischemia–… Superoxide dismutase
is a first line of defense against … aimed at mimicking superoxide dismutase was a natural …

… of human copper/zinc superoxide dismutase (SOD1) suppresses ischemia–reperfusion injury and subsequent development of graft coronary artery disease in murine …

M Tanaka, GK Mokhtari, RD Terry, LB Balsam, KH Lee… - Circulation, 2004 - Am Heart Assoc
Background— Ischemia–reperfusion injury is an important risk factor for graft coronary artery
disease (GCAD). We hypothesized that overexpression of SOD1 in donor hearts would …

Superoxide dismutase concentration and activity in familial amyotrophic lateral sclerosis

AC Bowling, EE Barkowski… - Journal of …, 1995 - Wiley Online Library
… To characterize further Cu/Zn SOD activity in FALS and investigate the possible involvement
of decreased activity in the disease process, we determined both the concentration and …

Therapeutic implications of superoxide dismutase and its importance in kinase drug discovery

N Kaur, AK Sharma, A Shakeel… - Current Topics in …, 2017 - ingentaconnect.com
… [20] Greenwald, RA Superoxide dismutase and catalase as therapeutic agents for human
diseases. … Liposomal recombinant human superoxide dismutase for the treatment of Peyronie’s …

Superoxide dismutase and the death of motoneurons in ALS

JS Beckman, AG Estévez, JP Crow, L Barbeito - Trends in neurosciences, 2001 - cell.com
… Amyotrophic lateral sclerosis (ALS) is a lethal disease that is … 1Sites of mutations in Cu–Zn
superoxide dismutase The … of the Zn-binding pocket of superoxide dismutase (SOD). A major …

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

JL Scott, C Gabrielides, RK Davidson… - … rheumatic diseases, 2010 - ard.bmj.com
… To prevent an accumulation of ROS-mediated damage chondrocytes produce a number of
antioxidant enzymes, including the superoxide dismutases (SOD), catalase and glutathione …

Zinc, copper, and superoxide dismutase in hepatocellular carcinoma.

KY Liaw, PH Lee, FC Wu, JS Tsai… - American Journal of …, 1997 - search.ebscohost.com
… with those subjects without known liver disease (631.73 ± 52.43 fig/L vs 845.53 ± 68.13
ftg/L). Our data suggest that the superoxide dismutase activity is impaired in the hepatoma tissue…