Paracellular bicarbonate flux across human cystic fibrosis airway epithelia tempers changes in airway surface liquid pH

IM Thornell, T Rehman, AA Pezzulo… - The Journal of …, 2020 - Wiley Online Library
… Airway epithelia control the pH of airway surface liquid (ASL), thereby optimizing respiratory
defences. Active H + and HCO 3 − secretion by airway epithelial cells produce an ASL that …

Gastroduodenal bicarbonate secretion

DL Hogan, MA Ainsworth… - Alimentary pharmacology …, 1994 - Wiley Online Library
epithelium is covered by an adherent mucus layer into which bicarbonate is secreted by
surface epithelial … (VIP) on duodenal surface epithelial bicarbonate secretion in the rat. Scand J …

Pendrin mediates bicarbonate secretion and enhances cystic fibrosis transmembrane conductance regulator function in airway surface epithelia

D Kim, J Huang, A Billet, A Abu-Arish… - American journal of …, 2019 - atsjournals.org
… current by approximately twofold in epithelial and nonepithelial cells. We … secretion across
airway surface epithelium during inflammation and enhances electrogenic Cl − secretion

Interleukin-17A induces bicarbonate secretion in normal human bronchial epithelial cells

JL Kreindler, CA Bertrand, RJ Lee… - … of Physiology-Lung …, 2009 - journals.physiology.org
… IL-17A-induced bicarbonate secretion was cystic fibrosis transmembrane conductance …
epithelial bicarbonate secretion and implicate a mechanism by which airway surface liquid …

Bicarbonate secretion and acid/base sensing by the intestine

HM Becker, UE Seidler - Pflügers Archiv-European Journal of Physiology, 2024 - Springer
… Major advances have been made in the assessment of surface epithelial function using
video-imaging and two-photon techniques to assess the intracellular and juxtamucosal pH in …

cAMP stimulates bicarbonate secretion across normal, but not cystic fibrosis airway epithelia.

JJ Smith, MJ Welsh - The Journal of clinical investigation, 1992 - Am Soc Clin Investig
bicarbonate secretion by CF tracheal epithelia. Our results suggest that HCO- secretion
This low ratio of airway fluid volume to secretory surface area, and the potentially high rate …

Damage to the gastric epithelium activates cellular bicarbonate secretion via SLC26A9 Cl/HCO3 exchange

ES Demitrack, M Soleimani… - American Journal of …, 2010 - journals.physiology.org
surface epithelial cells (26, 27). Because the disulfonic stilbene DIDS is known to inhibit
acid-induced gastric surface epithelial HCO 3 − secretion (… gastric HCO 3 − secretion. It remains …

Mechanisms of bicarbonate secretion in the pancreatic duct

MC Steward, H Ishiguro, RM Case - Annu. Rev. Physiol., 2005 - annualreviews.org
… an almost isotonic sodium bicarbonate solution. How it does … as a model for bicarbonate
transport in other epithelia. In the 10 … picture of ductal bicarbonate secretion. Those wishing to …

Bicarbonate secretion: a neglected aspect of colonic ion transport

HJ Binder, V Rajendran, V Sadasivan… - Journal of clinical …, 2005 - journals.lww.com
… the surface epithelial cell. Cl absorption occurs via an apical membrane Cl-HCO 3 exchange
(ie, DRA) that may (ie, Na-dependent) or may not (ie, Na-independent) be coupled to Na-H …

The application of bicarbonate recovers the chemical-physical properties of airway surface liquid in cystic fibrosis epithelia models

L Ferrera, V Capurro, L Delpiano, A Gianotti, O Moran - Biology, 2021 - mdpi.com
… depends on a balanced secretion of chloride and bicarbonate and the absorption … bicarbonate
secretion causes a lowering of the ASL pH which is involved in the change of the epithelia