Acid secretion and proton conductance in human airway epithelium

H Fischer, JH Widdicombe… - American Journal of …, 2002 - journals.physiology.org
… We report here that human airway surface epithelium shows secretion of H + into the airway
lumen regulated by mucosal histamine or ATP. The effect of histamine suggests that the …

[HTML][HTML] Molecular mechanisms of calcium-sensing receptor-mediated calcium signaling in the modulation of epithelial ion transport and bicarbonate secretion

R Xie, X Dong, C Wong, V Vallon, B Tang, J Sun… - Journal of Biological …, 2014 - ASBMB
epithelial ion transport and duodenal bicarbonate secretion (DBS). CaSR proteins have been
detected in mouse duodenal mucosae and human intestinal epithelialsurface epithelial

Gastroduodenal mucus bicarbonate barrier: protection against acid and pepsin

A Allen, G Flemström - American Journal of Physiology …, 2005 - journals.physiology.org
bicarbonate in this review is on the mechanisms and control of its secretion and the
establishment of a surface … the lumen and the gastric surface epithelium, and as discussed in this …

duodenal bicarbonate–mucosal protection, luminal chemosensing and acid–base balance

JD Kaunitz, Y Akiba - Alimentary pharmacology & therapeutics, 2006 - Wiley Online Library
… secretion14–16; (2) pH electrode studies suggest that epithelial bicarbonate secretion
creates a layer of neutral pH next to the mucosa17,18; (3) Helicobacter pylori infection …

Bicarbonate exporting transporters in the ovine ruminal epithelium

S Bilk, K Huhn, KU Honscha, H Pfannkuche… - Journal of Comparative …, 2005 - Springer
… pH, bicarbonate secretion by the ruminal epithelium seems … of bicarbonate exporting systems
in ruminal epithelial cells. … in primary cultured ruminal epithelial cells loaded with the pH-…

Ca2+ signaling and fluid secretion by secretory cells of the airway epithelium

RJ Lee, JK Foskett - Cell calcium, 2014 - Elsevier
… cells may exceed the volume of the surface epithelial cells by as much as 30-fold [27], [28].
The importance of submucosal gland fluid secretion is evidenced in the disease cystic fibrosis …

Duodenal epithelial sensing of luminal acid: role of carbonic anhydrases

M Sjöblom - Acta Physiologica, 2011 - Wiley Online Library
… –bicarbonate barrier provides a means of maintaining a virtually neutral pH at the epithelial
surface. … The enterocytes lining the duodenal epithelium secrete bicarbonate at higher rates …

A new role for bicarbonate secretion in cervico‐uterine mucus release

RW Muchekehu, PM Quinton - The Journal of physiology, 2010 - Wiley Online Library
… luminal bath to inhibit accessible surfaces and achieve maximal effect. … secretory capacity
of these cells forming the epithelial compartment, where it is conceivable that the bicarbonate

Role of epithelial HCO3 transport in mucin secretion: lessons from cystic fibrosis

PM Quinton - American Journal of Physiology-Cell …, 2010 - journals.physiology.org
… quite hypotonic sweat secretion on the skin surface. In contrast… regulator-dependent
bicarbonate secretion. J Clin Invest 119… for bicarbonate secretion in cervico-uterine mucus …

Evidence that Calu-3 human airway cells secrete bicarbonate

MC Lee, CM Penland… - American Journal of …, 1998 - journals.physiology.org
… primarily in the apical membranes of epithelia. Lung disease is the … from airway surface liquid,
and the pH of the secreted fluid … Reduced fluid secretion by serous cells should reduce the …