Pulmonary surfactant protein A modulates the cellular response to smooth and rough lipopolysaccharides by interaction with CD14

H Sano, H Sohma, T Muta, S Nomura… - The Journal of …, 1999 - journals.aai.org
… SP-A modulates LPS-elicited cellular responses, we further examined the … response to
rough LPS can be enhanced. We propose that SP-A modulates LPS-induced cellular responses

Pulmonary surfactant protein D inhibits lipopolysaccharide (LPS)-induced inflammatory cell responses by altering LPS binding to its receptors

M Yamazoe, C Nishitani, M Takahashi, T Katoh… - Journal of biological …, 2008 - ASBMB
surfactant protein A, and the coiled-coil neck and lectin domains of SP-D, was a weak inhibitor
of LPS-induced cell responses … -regulates inflammatory cell responses elicited by smooth …

Surfactant protein A directly interacts with TLR4 and MD-2 and regulates inflammatory cellular response: importance of supratrimeric oligomerization

C Yamada, H Sano, T Shimizu, H Mitsuzawa… - Journal of biological …, 2006 - ASBMB
… The purpose of the current study was to examine the binding of pulmonary surfactant protein
A (SP-A) to TLR4 and MD-2, which are critical signaling receptors for lipopolysaccharides (…

Immunoregulatory functions of surfactant proteins

JR Wright - Nature Reviews Immunology, 2005 - nature.com
… of the surfactant proteins SP-A and SP-D in regulating host immune defence and in modulating
inflammatory responses. … Collectins regulate multiple cellular responses in addition to …

The proteins of the surfactant system

J Johansson, T Curstedt… - European Respiratory …, 1994 - Eur Respiratory Soc
… syndrome, the clinical response to treatment with surfactant containing SP-B … cells. Whether
this synthesis contributes significant amounts of surfactant protein to the alveolar surfactant

[HTML][HTML] Interactions of surfactant protein A with epithelial cells and phagocytes

MJ Tino, JR Wright - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 1998 - Elsevier
Surfactant protein (SP) A was initially identified in surfactant … one of four surfactant-associated
proteins identified thus far, in … SP-A may interact with cells and regulate cell responses is a …

Surfactant Protein-A inhibits Aspergillus fumigatus-induced allergic T-cell responses

ST Scanlon, T Milovanova, S Kierstein, Y Cao… - Respiratory …, 2005 - Springer
… disruption of surfactant biophysics, changes in the hydrophobic surfactant protein B and C
[4… While SP-A is the most abundant and most extensively studied surfactant protein in the lung …

In defense of the lung: surfactant protein A and surfactant protein D

PS Kingma, JA Whitsett - Current opinion in pharmacology, 2006 - Elsevier
… The pulmonary collectins — surfactant proteins A (SP-A) and D (SP… surfactant homeostasis,
contributing to the physical structures of lipids in the alveoli and to the regulation of surfactant

Surfactant protein A and surfactant protein D in health and disease

RJ Mason, K Greene… - … Physiology-Lung Cellular …, 1998 - journals.physiology.org
Surfactant protein (SP) A and SP-D are collagenous glycoproteins with multiple functions …
proteins are calcium-dependent lectins and are structurally similar to mannose-binding protein

[HTML][HTML] Structure, processing and properties of surfactant protein A

FX McCormack - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 1998 - Elsevier
Surfactant protein A (SP-A) is a highly ordered, oligomeric glycoprotein that is secreted into …
of protein suggest diverse roles in pulmonary host defense and surfactant homeostasis, …