… Surfactant is comprised of phospholipids and proteins (10%), which predominantly include
the hydrophobic proteins surfactant protein (SP)-B and SP-C and the hydrophilic proteins SP-…

… immune proteins, termed surfactant proteins. Among these, … used as disease activity markers
for interstitial lung diseases. … SP-D translated from in vitro studies to human lung diseases. …

… diagnostic tool for specific lung diseases, we discuss this … and the presence of the surfactant
proteins in serum were not … , the absolute values of the surfactant proteins in sera were not …

… of surfactant protein abnormalities to the development of chronic lung injury in a familial form
of interstitial lung disease. … interstitial lung disease underwent laboratory investigation of …

… This protein is also an active component of some clinical surfactant preparations (27–29).
A … interactions with other surfactant proteins has been reviewed in detail elsewhere (30–33). …

… Through the study and improved understanding of surfactant over the decades, there is …
interstitial lung diseases (chILD) in the context of surfactant protein disorders. Surfactant protein …

… (chILD) comprise a broad spectrum of diseases. Besides the genetically defined surfactant
… involve the alveolar surfactant region, possibly affecting the surfactant proteins SP-B and SP-…

… pathological changes of the lung in the diseases, including pulmonary fibrosis, collagen
vascular diseases complicated with interstitial lung disease, pulmonary alveolar proteinosis, …

… One study demonstrated that surfactant protein levels can be used as an indicator of lung
injury and poor outcomes in H1N1 viral infections (47), and another showed that SP-A and SP-…

… In airway surfactant, there was little or no mature SP-B or SP-C; SP-A content was … surfactant
composition and function. We propose that a dominant negative effect on surfactant protein …