Inhibition of AURKA reduces proliferation and survival of gastrointestinal cancer cells with activated KRAS by preventing activation of RPS6KB1

L Wang-Bishop, Z Chen, A Gomaa, AC Lockhart… - Gastroenterology, 2019 - Elsevier
… of gastrointestinal cancer cell lines with activated KRAS, we found AURKA to phosphorylate
RPS6KB1, promoting cell proliferation and survival … the growth of gastrointestinal tumors with …

Bromelain and N-acetylcysteine inhibit proliferation and survival of gastrointestinal cancer cells in vitro: significance of combination therapy

A Amini, S Masoumi-Moghaddam, A Ehteda… - … & Clinical Cancer …, 2014 - Springer
gastrointestinal cancer cells of different origin, chemosensitivity and phenotype. MKN45 and
KATO-III are gastric cancer cell … and NAC on gastrointestinal cancer cells with added value …

Osteopontin Promotes Integrin Activation through Outside-In and Inside-Out Mechanisms: OPN-CD44V Interaction Enhances Survival in Gastrointestinal Cancer Cells

JL Lee, MJ Wang, PR Sudhir, GD Chen, CW Chi… - Cancer research, 2007 - AACR
… ) is essential for survival and growth of normal adhering cells, whereas cancer cells are
able … the regulation of growth and survival of neoplastic cells through affecting integrin-mediated …

Use of interfering RNA to investigate the role of endogenous gastrin in the survival of gastrointestinal cancer cells

AM Grabowska, J Hughes, SA Watson - British journal of cancer, 2007 - nature.com
… and anti-apoptotic effects on gastrointestinal (GI) cancers. A small interfering RNA (siRNA) …
in GI cancer cell survival. Downregulation of the gastrin gene in siRNA-transfected cells was …

Roles of ion and water channels in the cell death and survival of upper gastrointestinal tract cancers

A Shiozaki, Y Marunaka, E Otsuji - … in Cell and Developmental Biology, 2021 - frontiersin.org
… have been detected in upper gastrointestinal tract (UGI) cancers. Current information on …
survival of UGI cancer cells was reviewed herein, and the potential of their regulation for cancer

Cancer stem cells in human gastrointestinal cancer

H Taniguchi, C Moriya, H Igarashi, A Saitoh… - Cancer …, 2016 - Wiley Online Library
… Combining several therapeutic approaches such as surgery, endoscopic therapy, chemotherapy,
and radiation may improve survival in patients with gastrointestinal cancer. However, …

Deregulated GSK3 sustains gastrointestinal cancer cells survival by modulating human telomerase reverse transcriptase and telomerase

W Mai, K Kawakami, A Shakoori, S Kyo… - Clinical Cancer …, 2009 - AACR
… that survival of gastrointestinal, pancreatic, and liver cancer cells … against these cancer
cells and colon cancer xenografts in … inhibition were observed in normal cells or vital organs. …

Apoptosis—programmed cell death and its relevance to gastrointestinal epithelium: survival signal from the matrix

AS Tarnawski, I Szabo - Gastroenterology, 2001 - Elsevier
… , Bcl-2 expression may be related to increased activity of telomerase, 50 responsible for cell
survival of cancer cells. Recent studies also show that FAK is overexpressed in cancer cells, …

Characterization of a side population of cancer cells from human gastrointestinal system

N Haraguchi, T Utsunomiya, H Inoue, F Tanaka… - … cells, 2006 - academic.oup.com
… of cancer death. In this study, we tried to identify cancer SP cells in human gastrointestinal
system cancer cell … Over-expression of CEACAM6 promotes cell survival under anchorage-…

Defined factors induce reprogramming of gastrointestinal cancer cells

N Miyoshi, H Ishii, K Nagai, H Hoshino… - Proceedings of the …, 2010 - National Acad Sciences
… Such structures, however, usually did not survive within the densely populated Central …
-Holocene, preserve Stone Age structures that did not survive on land. Yet, the discovery of these …