… In this large-scale GWAS of gallstone disease, we identified 4 loci in genes that have
putative functions in cholesterol metabolism and transport, and sulfonylation of bile acids or …

… Two loci on chromosome 1p were linked significantly to symptomatic gallstone disease within
the cohort … In addition, a number of loci were linked above the suggestive threshold with …

… GWA meta- analysis with FinnGen data revealed a total of 63 loci associated with gallstone
disease (p < 5 × 10−8). Of these, 43 of 63 were identified in the UKB GWAS, 1 of 63 was …

… , indicating that cholelithiasis is a polygenic complex disease. Quantitative trait locus analysis
… The disease susceptibility loci were mapped by identifying the genomic regions where the …

… gallstone-susceptibility loci in inbred mice provide the basis for studies of the corresponding
genes in patients with gallstones. … to complications of cholelithiasis and gallbladder disease. …

… In this study, we used these publicly available summary results from the UK Biobank to
identify genetic susceptibility loci for gallstone disease. The genetic associations identified were …

… strongest risk factors of gallstone disease. Body mass index (… The role of cholesterol
supersaturation in gallstone formation … ) associated with gallstone disease susceptibility …

… susceptibility in the causation of gallbladder diseases was recognized as early as 1937.
A major gallstone susceptibility locus (Lith1) was identified in 1995 by quantitative trait locus …

… of the concordance rates of symptomatic gallstone disease (GSD) between … locus (QTL)
analysis have identified and localized genomic regions associated with gallstone susceptibility …

… There is compelling evidence for familial clustering of the disease, and an increased con…
ABCG5/8 locus was initially identified as a susceptibility factor for gallstone disease in a genome…