[HTML][HTML] Involvement of p38 MAPK in synaptic function and dysfunction

C Falcicchia, F Tozzi, O Arancio, DM Watterson… - International journal of …, 2020 - mdpi.com
… of p38 MAPK in the regulation of synaptic plasticity and its implication in an animal model of
neurodegeneration. In particular, recent evidence suggests the p38 MAPK α … synaptic and …

MAPK cascade signalling and synaptic plasticity

GM Thomas, RL Huganir - Nature Reviews Neuroscience, 2004 - nature.com
… Another recently emerging story is the involvement of a 'parallel' but distinct kinase cascade
leading to the activation of p38 MAPK, which might control distinct forms of synaptic plasticity…

Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system

K Takeda, H Ichijo - Genes to Cells, 2002 - Wiley Online Library
p38 MAPK inhibitors, and its availability has greatly contributed to understanding of the
biological functions of p38 MAPKs. … of the p38 pathway in the control of synaptic function has only …

The role of p38 MAPK and its substrates in neuronal plasticity and neurodegenerative disease

SAL Corrêa, KL Eales - Journal of signal transduction, 2012 - Wiley Online Library
… we will give an overview of p38 MAPK localisation, activation, and the functional role of this
… of the p38 MAPK cascade during synaptic plasticity in the hippocampus. Although p38 MAPK

[HTML][HTML] p38 MAPK inhibition improves synaptic plasticity and memory in angiotensin II-dependent hypertensive mice

H Dai, W Hu, L Jiang, L Li, X Gaung, Z Xiao - Scientific reports, 2016 - nature.com
p38 MAPK inhibition rescues hippocampal LTP deficit To investigate synaptic functional
changes, we performed extracellular electrophysiological recordings on hippocampal slices at …

[HTML][HTML] The p38MAPK-MK2 Signaling Axis as a Critical Link Between Inflammation and Synaptic Transmission

E Beamer, SAL Corrêa - Frontiers in cell and developmental biology, 2021 - frontiersin.org
… of synaptic plasticity underlying cognitive functions. Finally, we discuss the potential of the
p38 MAPK -… , we propose that the p38 MAPK -MK2 signaling axis controls synapse strength in …

Targeting p38 MAPK pathway for the treatment of Alzheimer's disease

L Munoz, AJ Ammit - Neuropharmacology, 2010 - Elsevier
… protein used as a marker for synaptic function) and significantly improved behavioural
deficits. These outcomes imply that p38 MAPK inhibitors could be suitable disease modifying …

[HTML][HTML] Prions activate a p38 MAPK synaptotoxic signaling pathway

C Fang, B Wu, NTT Le, T Imberdis, RCC Mercer… - PLoS …, 2018 - journals.plos.org
… morphology, we found that the p38 MAPK inhibitor prevented the PrP Sc -… p38 MAPK
plays an essential role in mediating the toxic effects of PrP Sc on synaptic structure and function

MAPK, β-amyloid and synaptic dysfunction: the role of RAGE

N Origlia, O Arancio, L Domenici… - Expert review of …, 2009 - Taylor & Francis
… able to induce an impairment of synaptic function in the hippocampus and entorhinal cortex
… of the role of p38 MAPK in neuronal dysfunction. Phosphorylation of p38 MAPK selectively …

p38 MAP kinase mediates both short-term and long-term synaptic depression in Aplysia

Z Guan, JH Kim, S Lomvardas, K Holick… - Journal of …, 2003 - Soc Neuroscience
… The sensory-to-motor neuron synapses of Aplysia show two opposing types of synaptic
activates p38 MAP kinase and that 5-HT inhibits the kinase. In contrast, ERK (p42) MAP kinase is …