… Accordingly, in this review, we focus on the molecular mechanisms underlying the
dysfunction of excitatory synapses in AD and discuss potential disease-modifying strategies. …

… early AD (Alzheimer's disease) may be due to synaptic dysfunction … synaptic loss and
neurodegeneration occurs. Soluble Aβ oligomers can rapidly disrupt synaptic memory mechanisms …

… in various other neurodegenerative diseases or, more … is uncovering more about synaptic
function and the multiple … in synaptic biology and specialists in neurogenerative disease to the …

… mechanisms of synaptic plasticity. Recently, we have reported the mechanism of the synapse
… hyperphosphorylation and synapse dysfunction. Thus, understanding the oxidative stress …

… ► Alzheimer’s disease is the result of synaptic dysfunction and neuronal loss. ► Mouse
models of AD recapitulate the synaptic dysfunction phenotype. ► Memory deficits are …

… 85] indicate a failure of local neuronal regulatory mechanisms of synaptic plasticity and make
a primary disturbance of synapse turnover very likely. This assumption is further supported …

… Aβ assemblies in causing synaptic dysfunction and cognitive … mechanisms responsible
of Aβ-induced synaptic failure have been identified. The first and most important mechanism …

… Synaptic scaling is a compensatory homeostatic mechanism which maintains the excitatory
… synapse loss. In this review, several possible mechanisms of synaptic scaling are described. …

… might be an early component of synaptic dysfunction in Alzheimer’s disease, and that
presenilins can affect synapses via a loss-of-function mechanism, as opposed to the gain-of-…

… genes on synapse dysfunction. Since endocytic traffic is essential for synaptic function, we
reviewed Aβ-dependent and independent mechanisms of the earliest synaptic dysfunction in …