The role of aquaporin-4 in synaptic plasticity, memory and disease

JA Hubbard, JI Szu, DK Binder - Brain research bulletin, 2018 - Elsevier
… roles of AQP4 in cognition and the functional consequences of AQP4 dysregulation … these
studies on how AQP4 impacts synaptic plasticity and learning and … AQP4 in synaptic plasticity

Aquaporin-4 water channels and synaptic plasticity in the hippocampus

HE Scharfman, DK Binder - Neurochemistry international, 2013 - Elsevier
AQP4 influences synaptic plasticity, and therefore is one of the ways that astrocytes regulate
synaptic plasticity, we used hippocampal slices from AQP4 … The Schaffer collateral synapse

The role of astrocytic aquaporin-4 in synaptic plasticity and learning and memory

JI Szu, DK Binder - Frontiers in integrative neuroscience, 2016 - frontiersin.org
… of AQP4AQP4 plays an important role in regulating synaptic plasticity in the hippocampus
and amygdala. Table 1 outlines the comparison of synaptic plasticity between WT and AQP4-…

Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4

VA Skucas, IB Mathews, J Yang, Q Cheng… - Journal of …, 2011 - Soc Neuroscience
Aquaporin-4 (AQP4) is the major water channel in the CNS and is primarily expressed in
astrocytes. Little is known about the potential for AQP4 to influence synaptic plasticity, although …

Aquaporin-4 deficiency impairs synaptic plasticity and associative fear memory in the lateral amygdala: involvement of downregulation of glutamate transporter-1 …

YK Li, F Wang, W Wang, Y Luo, PF Wu… - …, 2012 - nature.com
… Our finding that AQP4 deficiency impaired synaptic plasticity in amygdala raised the
possibility that loss of AQP4 might alter amygdala-dependent learning behavior. To test this …

Astrocytic water channel aquaporin-4 modulates brain plasticity in both mice and humans: a potential gliogenetic mechanism underlying language-associated …

J Woo, JE Kim, JJ Im, J Lee, HS Jeong, S Park… - Molecular …, 2018 - nature.com
… let alone in brain plasticity. To unravel the role of astrocytic AQP4 in brain plasticity, we undertook
a … The main objective of this study is to elucidate the role of AQP4 in brain plasticity and …

The potential roles of aquaporin 4 in Alzheimer's disease

YL Lan, J Zhao, T Ma, S Li - Molecular neurobiology, 2016 - Springer
… Currently, it has been suggested that AQP4 influences synaptic plasticity, and AQP4 deficiency
may impair learning and memory, in part, through glutamate transporter-1 (GLT-1). AQP4

Involvement of aquaporin 4 in astrocyte function and neuropsychiatric disorders

M Xiao, G Hu - CNS neuroscience & therapeutics, 2014 - Wiley Online Library
… Adult AQP4 −/− mice exhibited defects in consolidation memory and location-specific object
synaptic plasticity. These findings highlight that AQP4 has a role in synaptic plasticity and …

Aquaporin-4 surface trafficking regulates astrocytic process motility and synaptic activity in health and autoimmune disease

S Ciappelloni, D Bouchet, N Dubourdieu… - Cell reports, 2019 - cell.com
plasticity is partly mediated by ion and water fluxes, which rely on the water channel aquaporin-4
(AQP4). … astrocytes the dynamic distribution of the AQP4 isoforms M1 and M23. Surface …

Expression of the astrocyte water channel aquaporin-4 in the mouse brain

JA Hubbard, MS Hsu, MM Seldin, DK Binder - ASN neuro, 2015 - journals.sagepub.com
… of AQP4 in synaptic plasticity in the hippocampus, the widespread and region-specific
expression pattern of AQP4 … but also local synaptic plasticity and function in distinct brain circuits. …