Ubiquitin-proteasome-mediated local protein degradation and synaptic plasticity

AN Hegde - Progress in neurobiology, 2004 - Elsevier
… long-term synaptic plasticity. Also, using synaptic tagging theory of synapse-specific plasticity,
I provide a model on the possible roles and regulation of local protein degradation by the …

Protein homeostasis and synaptic plasticity

IJ Cajigas, T Will, EM Schuman - The EMBO journal, 2010 - embopress.org
… forms of long‐term synaptic plasticity. More recently, several studies have highlighted a
function for protein degradation by the ubiquitin proteasome system in synaptic plasticity. These …

Proteolysis, synaptic plasticity and memory

AN Hegde - Neurobiology of learning and memory, 2017 - Elsevier
… on the role of protein synthesis in long-term synaptic plasticity and memory. Research that …
long-term synaptic plasticity. Protein degradation that functions to sculpt synapses and thus in …

Synaptic protein degradation by the ubiquitin proteasome system

B Bingol, EM Schuman - Current opinion in neurobiology, 2005 - Elsevier
… that results in changes in synaptic strength. Recent experiments have highlighted a role for
… is, regulated protein degradation via the ubiquitin–proteasome system, in synaptic plasticity. …

Targeted protein degradation and synapse remodeling by an inducible protein kinase

DTS Pak, M Sheng - Science, 2003 - science.org
… Long-lasting forms of synaptic plasticity require new gene expression and protein synthesis
(1–3). Some activity-inducible genes may mediate the conversion of short-term responses to …

[HTML][HTML] Recent insights on principles of synaptic protein degradation

LD Cohen, NE Ziv - F1000Research, 2017 - ncbi.nlm.nih.gov
… face, we feel that even before considering issues of synaptic plasticity and neurodegenerative
disorders, principles of constitutive synaptic protein degradation represent a fascinating …

The ubiquitin–proteasome system as a critical regulator of synaptic plasticity and long-term memory formation

TJ Jarome, FJ Helmstetter - Neurobiology of learning and memory, 2013 - Elsevier
… propose a model explaining how protein degradation may be contributing to various aspects
of memory and synaptic plasticity. We conclude that protein degradation may be the major …

Synaptic protein degradation in memory reorganization

BK Kaang, JH Choi - Synaptic Plasticity: Dynamics, Development and …, 2012 - Springer
… the abundance of certain proteins. Accumulating evidence … the mechanism of UPS regulation
following synaptic activity. Then, we … We will introduce the role of the protein degradation–…

The ubiquitin-proteasome pathway and synaptic plasticity

AN Hegde - Learning & memory, 2010 - learnmem.cshlp.org
… In the recent past, a new molecular mechanism that modulates both short-term and long-term
synaptic plasticity has emerged: protein degradation through the ubiquitin-proteasome …

The roles of protein expression in synaptic plasticity and memory consolidation

T Rosenberg, S Gal-Ben-Ari, DC Dieterich… - Frontiers in molecular …, 2014 - frontiersin.org
protein synthesis and protein degradation is important for synaptic plasticity, as inhibition of
the proteasome or protein … of both proteasome activity and protein synthesis has no effect (…