Synergistic interaction between amyloid and tau predicts the progression to dementia

TA Pascoal, S Mathotaarachchi, M Shin… - Alzheimer's & …, 2017 - Elsevier
… Notably, our regression models confirmed that the synergistic interaction, rather than the
sum of individual contributions of Aβ+ and p-tau+ status, determined worse baseline …

Synergistic interaction of high blood pressure and cerebral beta-amyloid on tau pathology

T Kim, D Yi, MS Byun, H Ahn, JH Jung, N Kong… - Alzheimer's research & …, 2022 - Springer
… A novel point of this study is that we specifically identified that high SBP and DBP in late-life,
but not a history of hypertension, synergistically interact with in vivo cerebral amyloid

A novel, synergistic interaction between 17 β-estradiol and glutathione in the protection of neurons against β-amyloid 25–35-induced toxicity in vitro

KE Gridley, PS Green, JW Simpkins - Molecular pharmacology, 1998 - ASPET
… did not interact synergistically with E2, nor were any synergistic interactions observed …
Based on these data, we propose an estrogen-receptor independent synergistic interaction

Synergistic interactions are prevalent in catalytic amyloids

LR Marshall, M Jayachandran… - …, 2020 - Wiley Online Library
… Previously, we reported synergistic interactions in catalytic amyloids formed … synergistic
interactions within a family of amyloid fibrils, exploring the results of functional group interactions, …

Amyloid-β and hyperphosphorylated tau synergy drives metabolic decline in preclinical Alzheimer's disease

TA Pascoal, S Mathotaarachchi, S Mohades… - Molecular …, 2017 - nature.com
… In conclusion, the proposed synergistic interaction between amyloid-β and tau supports
the idea of a more integrative model of AD, although it does not explicitly refute the baptist or …

Synergistic effect of β-amyloid and neurodegeneration on cognitive decline in clinically normal individuals

EC Mormino, RA Betensky, T Hedden… - JAMA …, 2014 - jamanetwork.com
… We found that Aβ and ND synergistically contributed to cognitive change, suggesting that …
Although the mechanism underlying this synergistic effect of Aβ and ND remains unclear, it is …

Synergy between amyloid-β and tau in Alzheimer's disease

MA Busche, BT Hyman - Nature neuroscience, 2020 - nature.com
… Indeed, lipid-metabolism-related genes are related to the spread of both Aβ and tau
pathology in human AD 35 , and recent tau–Aβ-PET revealed a synergistic interaction between …

Synergistic interactions between repeats in tau protein and Aβ amyloids may be responsible for accelerated aggregation via polymorphic states

Y Miller, B Ma, R Nussinov - Biochemistry, 2011 - ACS Publications
Interactions between the Aβ amyloid and the tau protein are … the tendency to form stable
interactions between Aβ and tau … interactions, electrostatic interactions, polar interactions, and …

Synergistic interactions between Aβ, tau, and α-synuclein: acceleration of neuropathology and cognitive decline

LK Clinton, M Blurton-Jones, K Myczek… - Journal of …, 2010 - Soc Neuroscience
interactions between Aβ, tau, and α-syn in vivo. Importantly, these mice also allow us to
examine the combined impact of triple brain amyloidosissynergistic amyloidogenic interactions

Synergistic effect of amyloid-β and tau disrupts neural circuits

T Tripathi, P Kalita - ACS chemical neuroscience, 2019 - ACS Publications
… of amyloid-β (Aβ) plaques and tau-based neurofibrillary tangles. Although studies have
shown that the interaction … A recent study revealed that the interaction between Aβ and tau …