Tumor necrosis factor α induces sustained signaling and a prolonged and unremitting inflammatory response in rheumatoid arthritis synovial fibroblasts

A Lee, Y Qiao, G Grigoriev, J Chen… - Arthritis & …, 2013 - Wiley Online Library
… character of synovial inflammation in rheumatoid arthritis (RA) … synovitis, we investigated
the molecular mechanisms that govern the tumor necrosis factor α (TNFα)–driven inflammatory

… membrane and joint effusion volumes in rheumatoid arthritis and osteoarthritis. Comparison with the macroscopic and microscopic appearance of the synovium

M Østergaard, M Stoltenberg… - Arthritis & …, 1997 - Wiley Online Library
Synovial inflammation and 9 separate tissue characteristics were graded … synovial membrane
volumes were correlated with the overall histologic assessment of synovial inflammation (…

Pre-rheumatoid arthritis: predisposition and transition to clinical synovitis

WP Arend, GS Firestein - Nature Reviews Rheumatology, 2012 - nature.com
… myeloid cells in the synovial microvasculature and tissue. 6) … synovium. 10) In both sites,
the classical and alternative pathways of complement are activated. 11) Synovium inflammation

Synovial inflammation in osteoarthritis progression

E Sanchez-Lopez, R Coras, A Torres… - … Reviews Rheumatology, 2022 - nature.com
Synovial inflammation is present in the OA joint and has … involved in OA-related synovial
inflammation could form the basis … This Review focuses on the biology of the OA synovium, how …

Chemokines in synovial inflammation in rheumatoid arthritis: basic and clinical aspects

K Tani, T Shimizu, Y Motoki, S Sone - Modern rheumatology, 2002 - Taylor & Francis
… accumulating in synovial tissue contribute to the pathogenesis of synovitis.In this review, we
focus on the role of chemokines in the pathogenesis of synovial inflammation in RA, and dis…

Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis

E Choy - Rheumatology, 2012 - academic.oup.com
… by stimulating other mononuclear cells, synovial fibroblasts, chondrocytes and osteoclasts.
… causes synovial inflammation. In addition to their articular effects, pro-inflammatory cytokines …

Rheumatoid arthritis: sequences

PN Scutellari, C Orzincolo - European journal of radiology, 1998 - Elsevier
… Hyperemia caused by synovial inflammation leads to regional or periarticular … Synovial
inflammation, similar to that observed in intra-articular structures, occurs in the synovial lining of …

Synovial phenotypes in rheumatoid arthritis correlate with response to biologic therapeutics

G Dennis, CTJ Holweg, SK Kummerfeld… - Arthritis research & …, 2014 - Springer
… that patients who displayed this inflammatory synovial phenotype would have the best clinical
… with the inflammatory lymphoid phenotype. To test the ability of these predefined synovial

Synovial inflammation does not change in the absence of effective treatment: implications for the use of synovial histopathology as biomarker in early phase clinical …

D Baeten, J Houbiers, E Kruithof… - Annals of the …, 2006 - ard.bmj.com
… in synovial inflammatory infiltration were noted. Conclusions: Despite variations in global
disease activity, synovial inflammatory … The lack of a placebo effect on synovial markers of …

Synovial tissue macrophages and joint erosion in rheumatoid arthritis.

G Yanni, A Whelan, C Feighery… - Annals of the rheumatic …, 1994 - ard.bmj.com
… The cumulative effect of synovial inflammation is represented by the increasing … initiating
and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum 1992; 35: 729-35. …