Systematic control of protein interaction using a modular ER/K α-helix linker
S Sivaramakrishnan… - Proceedings of the …, 2011 - National Acad Sciences
… frequency of interaction of two proteins or protein domains attached to its ends. We find that
varying the ER/K α-helix length systematically alters the frequency of interaction regardless …
varying the ER/K α-helix length systematically alters the frequency of interaction regardless …
Systematic discovery of new recognition peptides mediating protein interaction networks
… such interaction motifs exist, it is likely that many interactions are mediated by those not yet
discovered. Here we perform the first systematic … results of genome-scale interaction datasets. …
discovered. Here we perform the first systematic … results of genome-scale interaction datasets. …
Systematic targeting of protein–protein interactions
… Over the past decade, protein–protein interactions (PPIs) have gone from being neglected
… : how to target large protein surfaces with specificity. Several systematic and complementary …
… : how to target large protein surfaces with specificity. Several systematic and complementary …
A ligand-reversible dimerization system for controlling protein–protein interactions
CT Rollins, VM Rivera, DN Woolfson… - Proceedings of the …, 2000 - National Acad Sciences
… This system is much faster than transcriptional regulatory systems for controlling protein
production; we have used regulated secretion of insulin to transiently correct glucose levels in a …
production; we have used regulated secretion of insulin to transiently correct glucose levels in a …
Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme
C Jeronimo, D Forget, A Bouchard, Q Li, G Chua… - Molecular cell, 2007 - cell.com
… Our results define a high-density protein interaction network for the mammalian transcription
machinery and uncover multiple regulatory factors that target the transcription machinery. …
machinery and uncover multiple regulatory factors that target the transcription machinery. …
Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets
A Vinayagam, TE Gibson, HJ Lee… - Proceedings of the …, 2016 - National Acad Sciences
… control context where the “state space” of a control system is the space of values the “state
variables” can attain. For a protein–protein interaction (… Hence, we systematically analyzed the …
variables” can attain. For a protein–protein interaction (… Hence, we systematically analyzed the …
Controllability of protein-protein interaction phosphorylation-based networks: Participation of the hub 14-3-3 protein family
… Systematic studies of human protein-protein interactions are indispensable for deciphering
the molecular networks that underlie cellular phenotypes 25 . The cellular responses to …
the molecular networks that underlie cellular phenotypes 25 . The cellular responses to …
Methods for analyzing and quantifying protein–protein interaction
Syafrizayanti, C Betzen, JD Hoheisel… - Expert review of …, 2014 - Taylor & Francis
… quantitatively in order to properly understand protein interplay. … available for analysis of
protein–protein interactions. … of the Y2H system are – beside others – that the interaction takes …
protein–protein interactions. … of the Y2H system are – beside others – that the interaction takes …
Global approaches to protein–protein interactions
G Drewes, T Bouwmeester - Current opinion in cell biology, 2003 - Elsevier
… , for example global protein–protein interaction networks on a … comprehensive, cellular
protein–protein interaction maps. … system was the only suitable global approach to chart protein…
protein–protein interaction maps. … system was the only suitable global approach to chart protein…
Systematic protein–protein interaction mapping for clinically relevant human GPCR s
K Sokolina, S Kittanakom, J Snider… - Molecular systems …, 2017 - embopress.org
… In this study, we report the first systematic … system to identify human GPCR interactions,
we tested known GPCR‐interacting proteins in MYTH, confirming 24% of tested interactions…
we tested known GPCR‐interacting proteins in MYTH, confirming 24% of tested interactions…
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