Systematic control of protein interaction using a modular ER/K α-helix linker

S Sivaramakrishnan… - Proceedings of the …, 2011 - National Acad Sciences
… frequency of interaction of two proteins or protein domains attached to its ends. We find that
varying the ER/K α-helix length systematically alters the frequency of interaction regardless …

Systematic discovery of new recognition peptides mediating protein interaction networks

V Neduva, R Linding, I Su-Angrand, A Stark, F Masi… - PLoS …, 2005 - journals.plos.org
… such interaction motifs exist, it is likely that many interactions are mediated by those not yet
discovered. Here we perform the first systematic … results of genome-scale interaction datasets. …

Systematic targeting of proteinprotein interactions

AE Modell, SL Blosser, PS Arora - Trends in pharmacological sciences, 2016 - cell.com
… Over the past decade, proteinprotein interactions (PPIs) have gone from being neglected
… : how to target large protein surfaces with specificity. Several systematic and complementary …

A ligand-reversible dimerization system for controlling proteinprotein interactions

CT Rollins, VM Rivera, DN Woolfson… - Proceedings of the …, 2000 - National Acad Sciences
… This system is much faster than transcriptional regulatory systems for controlling protein
production; we have used regulated secretion of insulin to transiently correct glucose levels in a …

Systematic analysis of the protein interaction network for the human transcription machinery reveals the identity of the 7SK capping enzyme

C Jeronimo, D Forget, A Bouchard, Q Li, G Chua… - Molecular cell, 2007 - cell.com
… Our results define a high-density protein interaction network for the mammalian transcription
machinery and uncover multiple regulatory factors that target the transcription machinery. …

Controllability analysis of the directed human protein interaction network identifies disease genes and drug targets

A Vinayagam, TE Gibson, HJ Lee… - Proceedings of the …, 2016 - National Acad Sciences
control context where the “state space” of a control system is the space of values the “state
variables” can attain. For a proteinprotein interaction (… Hence, we systematically analyzed the …

Controllability of protein-protein interaction phosphorylation-based networks: Participation of the hub 14-3-3 protein family

M Uhart, G Flores, DM Bustos - Scientific Reports, 2016 - nature.com
Systematic studies of human protein-protein interactions are indispensable for deciphering
the molecular networks that underlie cellular phenotypes 25 . The cellular responses to …

Methods for analyzing and quantifying proteinprotein interaction

Syafrizayanti, C Betzen, JD Hoheisel… - Expert review of …, 2014 - Taylor & Francis
… quantitatively in order to properly understand protein interplay. … available for analysis of
proteinprotein interactions. … of the Y2H system are – beside others – that the interaction takes …

Global approaches to proteinprotein interactions

G Drewes, T Bouwmeester - Current opinion in cell biology, 2003 - Elsevier
… , for example global proteinprotein interaction networks on a … comprehensive, cellular
proteinprotein interaction maps. … system was the only suitable global approach to chart protein

Systematic proteinprotein interaction mapping for clinically relevant human GPCR s

K Sokolina, S Kittanakom, J Snider… - Molecular systems …, 2017 - embopress.org
… In this study, we report the first systematicsystem to identify human GPCR interactions,
we tested known GPCR‐interacting proteins in MYTH, confirming 24% of tested interactions