Beneficial non-anticoagulant mechanisms underlying heparin treatment of COVID-19 patients

B Buijsers, C Yanginlar, ML Maciej-Hulme… - …, 2020 - thelancet.com
… We propose that therapeutic treatment with heparin/LMWH will interfere with several
pathological processes in COVID-19 patients, thereby increasing their survival rate. …

[HTML][HTML] Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19

C Conzelmann, JA Müller, L Perkhofer, KMJ Sparrer… - Clinical Medicine, 2020 - Elsevier
… opportunity for the treatment of COVID-19 disease by repurposing a long-serving medical
agent with an excellent history of clinical use, namely heparin. Heparin is best known as an …

Randomized trials of therapeutic heparin for COVID19: a meta‐analysis

M Sholzberg, BR da Costa, GH Tang… - … and practice in …, 2021 - Wiley Online Library
… the effects of therapeutic heparin in hospitalized patients with COVID19. … heparin is
beneficial in moderately ill patients but not in severely ill patients hospitalized with COVID19

Comprehensive landscape of heparin therapy for COVID-19

C Shi, W Tingting, JP Li, MA Sullivan, C Wang… - Carbohydrate …, 2021 - Elsevier
… Clinical observations found that systemic symptoms caused by … of heparin, we illustrate
both the preclinical and clinical evidence that heparin therapy has multiple effects for COVID-19. …

Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence

FMP Van Haren, C Page, JG Laffey, A Artigas… - Critical Care, 2020 - Springer
… , mechanically ventilated patients who received systemic anti-coagulation during their
hospital course had a lower hospital mortality (adjusted HR of 0.86 per day, 95% confidence …

Use of low-molecular-weight heparin in COVID-19 patients

CS Kow, SS Hasan - Journal of Vascular Surgery: Venous and …, 2020 - jvsvenous.org
… that respiratory infection is also responsible for a systemic procoagulant activity,3-5 which
… this evidence, heparin has become a cornerstone of the treatment against COVID-19, along …

Heparin in COVID-19 patients is associated with reduced in-hospital mortality: the multicenter Italian CORIST study

A Di Castelnuovo, S Costanzo… - Thrombosis and …, 2021 - thieme-connect.com
… Our findings are similar to those of Ayerbe et al, showing that heparin treatment was … with
COVID-19 admitted to 17 hospitals in Spain.[38] Additionally, focusing on LMWH therapy, …

Coagulopathy, thromboembolic complications, and the use of heparin in COVID-19 pneumonia

L Costanzo, FP Palumbo, G Ardita, PL Antignani… - Journal of Vascular …, 2020 - Elsevier
… distress syndrome, empirical systemic anticoagulation significantly reduced venous … ,
the addition of heparin can have a favorable impact on progression of COVID-19 infection. …

Heparin for moderately ill patients with Covid-19

M Sholzberg, GH Tang, H Rahhal, M AlHamzah… - medRxiv, 2021 - medrxiv.org
… We randomly assigned moderately ill hospitalized ward patients admitted for Covid-19 with
elevated D-dimer level to therapeutic or prophylactic heparin. The primary outcome was a …

… heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital …

M Sholzberg, GH Tang, H Rahhal, M AlHamzah… - bmj, 2021 - bmj.com
… In moderately ill patients with covid-19 and increased D-dimer levels admitted to hospital
wards, therapeutic heparin was not significantly associated with a reduction in the primary …