Beneficial non-anticoagulant mechanisms underlying heparin treatment of COVID-19 patients
B Buijsers, C Yanginlar, ML Maciej-Hulme… - …, 2020 - thelancet.com
… We propose that therapeutic treatment with heparin/LMWH will interfere with several
pathological processes in COVID-19 patients, thereby increasing their survival rate. …
pathological processes in COVID-19 patients, thereby increasing their survival rate. …
[HTML][HTML] Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19
… opportunity for the treatment of COVID-19 disease by repurposing a long-serving medical
agent with an excellent history of clinical use, namely heparin. Heparin is best known as an …
agent with an excellent history of clinical use, namely heparin. Heparin is best known as an …
Randomized trials of therapeutic heparin for COVID‐19: a meta‐analysis
… the effects of therapeutic heparin in hospitalized patients with COVID‐19. … heparin is
beneficial in moderately ill patients but not in severely ill patients hospitalized with COVID‐19…
beneficial in moderately ill patients but not in severely ill patients hospitalized with COVID‐19…
Comprehensive landscape of heparin therapy for COVID-19
C Shi, W Tingting, JP Li, MA Sullivan, C Wang… - Carbohydrate …, 2021 - Elsevier
… Clinical observations found that systemic symptoms caused by … of heparin, we illustrate
both the preclinical and clinical evidence that heparin therapy has multiple effects for COVID-19. …
both the preclinical and clinical evidence that heparin therapy has multiple effects for COVID-19. …
Nebulised heparin as a treatment for COVID-19: scientific rationale and a call for randomised evidence
FMP Van Haren, C Page, JG Laffey, A Artigas… - Critical Care, 2020 - Springer
… , mechanically ventilated patients who received systemic anti-coagulation during their
hospital course had a lower hospital mortality (adjusted HR of 0.86 per day, 95% confidence …
hospital course had a lower hospital mortality (adjusted HR of 0.86 per day, 95% confidence …
Use of low-molecular-weight heparin in COVID-19 patients
… that respiratory infection is also responsible for a systemic procoagulant activity,3-5 which
… this evidence, heparin has become a cornerstone of the treatment against COVID-19, along …
… this evidence, heparin has become a cornerstone of the treatment against COVID-19, along …
Heparin in COVID-19 patients is associated with reduced in-hospital mortality: the multicenter Italian CORIST study
A Di Castelnuovo, S Costanzo… - Thrombosis and …, 2021 - thieme-connect.com
… Our findings are similar to those of Ayerbe et al, showing that heparin treatment was … with
COVID-19 admitted to 17 hospitals in Spain.[38] Additionally, focusing on LMWH therapy, …
COVID-19 admitted to 17 hospitals in Spain.[38] Additionally, focusing on LMWH therapy, …
Coagulopathy, thromboembolic complications, and the use of heparin in COVID-19 pneumonia
L Costanzo, FP Palumbo, G Ardita, PL Antignani… - Journal of Vascular …, 2020 - Elsevier
… distress syndrome, empirical systemic anticoagulation significantly reduced venous … ,
the addition of heparin can have a favorable impact on progression of COVID-19 infection. …
the addition of heparin can have a favorable impact on progression of COVID-19 infection. …
Heparin for moderately ill patients with Covid-19
… We randomly assigned moderately ill hospitalized ward patients admitted for Covid-19 with
elevated D-dimer level to therapeutic or prophylactic heparin. The primary outcome was a …
elevated D-dimer level to therapeutic or prophylactic heparin. The primary outcome was a …
… heparin versus prophylactic heparin on death, mechanical ventilation, or intensive care unit admission in moderately ill patients with covid-19 admitted to hospital …
… In moderately ill patients with covid-19 and increased D-dimer levels admitted to hospital
wards, therapeutic heparin was not significantly associated with a reduction in the primary …
wards, therapeutic heparin was not significantly associated with a reduction in the primary …
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