[HTML][HTML] The need for paradigm shift: prognostic significance and implications of standard therapy-related systemic immunosuppression in glioblastoma for …

AA Stepanenko, AO Sosnovtseva, MP Valikhov… - Frontiers in …, 2024 - frontiersin.org
… -related (iatrogenic) systemic immunosuppression, long-… in Immunology (Systemic and
local immunosuppression in … , namely, tumor-related immunosuppression at baseline and the …

[PDF][PDF] Autologous haematopoietic stem cell transplantation for systemic lupus erythematosus: time for a paradigm shift?

T Alexander, F Hiepe - Clin Exp Rheumatol, 2017 - clinexprheumatol.org
Systemic lupus erythematosus (SLE) is a prototypical systemic autoimmune disease (AD) …
Supported by preclinical models, highdose immunosuppression followed by transplantation …

Immunotherapy for the adjunctive treatment of sepsis: from immunosuppression to immunostimulation. Time for a paradigm change?

J Leentjens, M Kox, JG van der Hoeven… - American journal of …, 2013 - atsjournals.org
… may vary and can ultimately lead to systemic inflammation and the subsequent signs and …
in the current paradigm shift toward more attention for the immunosuppressive phase of sepsis …

Paradigm shift in oncology: targeting the immune system rather than cancer cells

T Shekarian, S Valsesia-Wittmann, C Caux… - …, 2015 - academic.oup.com
… against cancer cells and less systemic toxicities. However, like … Recently, a paradigm
shift has been brought to the clinic with … Another unexpected immunosuppressive effect on …

A paradigm shift in therapeutic vaccination of cancer patients: the need to apply therapeutic vaccination strategies in the preventive setting

A Gray, AB Raff, M Chiriva‐Internati… - Immunological …, 2008 - Wiley Online Library
… of a systemic immune response. Although the local immunosuppression mediated by metastatic
… not normally lead to complete systemic immunosuppression, this process nevertheless …

[HTML][HTML] A paradigm shift in cancer immunotherapy: from enhancement to normalization

MF Sanmamed, L Chen - Cell, 2018 - cell.com
Harnessing an antitumor immune response has been a fundamental strategy in cancer
immunotherapy. For over a century, efforts have primarily focused on amplifying immune …

[HTML][HTML] Treatment of rheumatic immune-related adverse events due to cancer immunotherapy with immune checkpoint inhibitors—is it time for a paradigm shift?

K Chatzidionysiou, M Liapi, G Tsakonas… - Clinical …, 2021 - Springer
… of oncolytic viruses for initiating systemic antitumor activity and … , where the degree of
immunosuppression should be high … is still evident, systemic glucocorticoids should be …

[HTML][HTML] Paradigm shifts in the role of CD4+ T cells in keratoplasty

K Cunnusamy, PW Chen - Discovery medicine, 2010 - ncbi.nlm.nih.gov
systemic immunosuppressive drugs. In rodents, corneal allografts transplanted across entire
MHC and multiple minor histocompatibility barriers enjoy long-term survival in >50% of the …

Immunosuppressant‐induced oxidative stress and iron: a paradigm shift from systemic to intrahepatic abnormalities

T Akhtar, G Ali, N Sheikh - Oxidative Medicine and Cellular …, 2020 - Wiley Online Library
immunosuppressiveimmunosuppressive drug used clinically to lower the rate of
immunological rejection after solid organ transplantation [3]. It is well known that its …

Novel paradigms in systemic lupus erythematosus

T Dörner, R Furie - The Lancet, 2019 - thelancet.com
… methodological approach and ensuing classification system using anti-nuclear antibodies
as an entry criterion and weighted, hierarchically clustered criteria, constitute a paradigm shift