… present in systemic sclerosis (SSc) and impact on dysregulated fibroblast extracellular
matrix … In addition, immune-complex formed by autoAb and ubiquitous antigens including …

… Numerous HLA polymorphisms have been identified as SSc susceptibility factors, suggesting
a key role of immune dysregulation. Additionally, polymorphisms in a diverse group of non-…

… autoimmunity leading to tissue sclerosis. This chapter summarizes the current knowledge
about systemic sclerosis pathogenesis and reviews the role of immune imbalance and its …

… Systemic sclerosis (SSc) is a destructive connective tissue disease characterized by
dysregulation of the immune … Thus, these effects further implicate immune dysregulation in the …

… of systemic sclerosis. (a) Facial features of a young woman with diffuse cutaneous systemic
sclerosis (dcSSc… Thus, the nature of the relationship between immune dysregulation and SSc …

… Systemic sclerosis (SSc) is a heterogeneous autoimmune … progression and perhaps onset
of systemic sclerosis. In light of this … Innate immune dysregulation is key in SSc pathogenesis …

… Variants of CD247 may lead to impaired immune response and dysregulation of T-cell
activation. CD247 has been associated with susceptibility to SLE. CD247 rs2056626 (in addition …

… Systemic sclerosis (SSc) is a complex disease characterized by early microvascular
abnormalities, immune dysregulation and … of interlinked vascular injury and immune activation, …

… Pathogenesis of systemic sclerosis is mediated by several immune and inflammatory cells.
… Evidence for B cell involvement comes from multiple studies outlining dysregulated B cell …

… From the clinical standpoint, systemic sclerosis (SSc) is … associate profound immune-inflammatory
dysregulation, … innate and adaptive type 2 immune responses. Radical oxygen species …