Recent advances on pathogenesis and therapies in systemic sclerosis

N Yazawa, M Fujimoto, K Tamaki - Clinical reviews in allergy & …, 2007 - Springer
antibodieslipase (LPL), a key enzyme that hydrolyzes triglycerides, suggests a role of
autoimmunity for elevated serum triglyceride levels and atherosclerosis in patients with systemic

Serum lipid profile in patients with systemic sclerosis: relationship to the thyreometabolic state

PJ Kotyla, J Gozdzik, M Lewicki, AT Kotulska… - Rheumatology …, 2006 - Springer
… [1] concerning lipid-profile abnormalities in patients with limited systemic sclerosis. The paper
… However, in the light of our study, scleroderma itself minimized the influence of the thyroid …

MicroRNA-30c attenuates fibrosis progression and vascular dysfunction in systemic sclerosis model mice

Y Kanno, E Shu, H Niwa, M Seishima… - Molecular Biology Reports, 2021 - Springer
Systemic sclerosis (SSc) is characterized by peripheral … , α2AP can bind and activate adipose
triglyceride lipase (ATGL) [5], … d Paraffin sections were stained with α-SMA antibodies. e …

[HTML][HTML] Macrovascular involvement and systemic sclerosis

ETAM Godoi, AD Barbosa, JTAM Godoi… - Jornal Vascular …, 2009 - SciELO Brasil
Este artigo tem como objetivo revisar os aspectos descritos na literatura sobre o acometimento
da macrovasculatura na esclerose sistêmica e avaliar a ocorrência e distribuição das …

α2-Antiplasmin as a potential therapeutic target for systemic sclerosis

Y Kanno, E Shu - Life, 2022 - mdpi.com
… bind and activate adipose triglyceride lipase (ATGL), which is … anti-centromere antibodies
and anti-Scl70 antibodies in SSc … α2AP neutralizing antibodies attenuates anti-Scl70 antibody

Fibrosis development in HOCl-induced systemic sclerosis: a multistage process hampered by mesenchymal stem cells

ATJ Maria, K Toupet, M Maumus, P Rozier… - Frontiers in …, 2018 - frontiersin.org
… able to differentiate into adipocytes expressing lipoprotein lipase (Lpl), peroxisome proliferator-…
However, in this setting, we did not observe a reduction of anti-scl70 antibody production (…

Over-expression of TATA binding protein (TBP) and p53 and autoantibodies to these antigens are features of systemic sclerosis, systemic lupus erythematosus and …

R Chauhan, R Handa, TP Das… - Clinical & Experimental …, 2004 - academic.oup.com
antibodies and to determine, quantitatively, the expression level of p53 and TBP antigens in
heterogeneous Asian Indian patients with systemic sclerosis… The individual antibodies titre to …

mTOR inhibition rescues osteopenia in mice with systemic sclerosis

C Chen, K Akiyama, D Wang, X Xu, B Li… - Journal of Experimental …, 2015 - rupress.org
… To avoid off-target effect, we used IL4Rα neutralizing antibody to block IL4 signaling and
found decreased expression of p-mTOR and elevated expression of RUNX2 in Fbn1 +/− …

Accelerated atherosclerosis in autoimmune rheumatic diseases

Y Shoenfeld, R Gerli, A Doria, E Matsuura, MM Cerinic… - Circulation, 2005 - Am Heart Assoc
… patients with systemic sclerosis (SSc), 10 systemic vasculitides, 8 and systemic lupus …
Anti–lipoprotein lipase antibodies have been associated with elevated levels of triglycerides and …

Mesenchymal stem cell transplantation in tight-skin mice identifies miR-151-5p as a therapeutic target for systemic sclerosis

C Chen, D Wang, A Moshaverinia, D Liu, X Kou, W Yu… - Cell research, 2017 - nature.com
Systemic sclerosis (SSc), an autoimmune disease, may cause significant osteopenia due to
activation of the IL4Rα/mTOR pathway. Mesenchymal stem cell transplantation (MSCT) can …