… Polypharmacology and chemical biology studies are amassing interaction data at … level
to the larger network-wide level. We review some of the recent developments in systems-level …

… First, we provide an overview of existing chemical reporters and bioorthogonal reactions. …
in cellular systems. Third, we highlight the translation of one chemical reporter system from cell-…

… However, unless the systems biology is carried out … systems biology and discuss two
approaches that are helping to address such challenges: top-down and bottom-up systems biology. …

… a wide array of signals with a system of minimal size are met by … system turns the structural
complexity of glycans—a demanding but essentially mastered problem for analytical chemistry…

… extend systems biology to drug-target and ligand-target networks and are now known as 'systems
chemical biology' 134 , 'network pharmacology' 135 or 'systems pharmacology' 136 . …

… systems biology is thus a field with a broad conceptual basis. This book attempts to bring all
these concepts from the expert level to the general senior or first-year graduate student level …

… In both forward and inverse metabolic engineering, systems level models and
simulations are accelerating bio-based process development, resulting in reduced time to …

Systems biology and combination therapy in the quest for clinical efficacy | Nature Chemical
Biology … A systems or network biology approach to analyzing combination therapy relies on …

… layer (“organism-level systems biology”) is of special … door toward organism-level systems
biology. These technologies … for realizing the organism-level systems biology in mammals by …

… , will highlight the signal and stress dichotomy of ROS chemistry and how it affects biological
systems from a molecular, cellular and organismal level. In this spirit, the purpose of this …