… The Systolic Hypertension in Europe (Syst-Eur) study investigated whether antihypertensive
… complications in elderly patients with isolated systolic hypertension. Patients ≥60 years …

… double-blind Systolic Hypertension in Europe (Syst-Eur) trial, … On February 14, 1997, the
Syst-Eur trial was terminated early… , 7 we decided to extend the Syst-Eur trial into an open-label, …

… the Syst-Eur trial, which was a randomized, placebo-controlled, double-blind intervention
trial in elderly patients with isolated systolic hypertension. … with isolated systolic hypertension. …

… nitrendipine could prevent vascular dementia in older patients with isolated systolic
hypertension. The Syst-Eur trial stopped on Feb 14, 1997, according to predefined stopping rules, …

… Syst-Eur investigators meeting in March 1997, the decision was taken to keep the Syst-Eur …
article summarizes the rationale and protocol of this study, named Systolic Hypertension in …

… to extend the Syst-Eur trial into … , Systolic Hypertension in Europe Phase 2 (Syst-Eur 2),
which will last until the end of 2001. In this article, which is the second progress report of Syst-Eur …

… with isolated systolic hypertension, we extended the double-blind placebo-controlled Systolic
Hypertension in Europe (Syst-Eur) trial by an open-label follow-up study lasting 4 years. …

… Syst-Eur is a double-blind placebo-controlled outcome trial conducted in European patients
over 60 years of age with isolated systolic hypertension. … included in Syst-Eur. Cognitive …

… The Syst-Eur study investigated whether active antihypertensive treatment could reduce
cardiovascular complications in elderly patients with isolated systolic hypertension. Patients (2 …

… Finally, a meta-analysis partly based on Syst-Eur data showed that in older hypertensive
patients pulse pressure and not mean pressure is the major determinant of cardiovascular risk. …