… amino acid position 790 (T790M) is a molecular mechanism … T790M mutation is present in
about half of the lung cancer … the T790M mutation confers growth advantage to cancer cells, …

… non-small cell lung cancer (NSCLC). However, EGFR T790M mutation leads to resistance
to … agents against EGFR T790M mutation in the treatment of patients with advanced NSCLC. …

… the T790M mutation in patients with epidermal growth factor receptor (EGFR)-mutant lung
cancer … Preclinical data have suggested that T790M mutant cell lines have indolent growth, but …

… of the EGFR T790M mutation in a minor tumor population in 3.6… L858R mutation were found
in major populations of the tumor … mutations were identified by direct sequencing and mutant-…

… TKIs in EGFR mutant lung cancer patients ranges between 56… to EGFR TKIs, the T790M
mutation, have become available [… of the T790M mutation in lung cancer patients who progress …

… T790M predicts a favorable prognosis and indolent progression. However, rebiopsy to confirm
T790M … known regarding the differences among patients with or without T790M mutation. …

… However, investigations into the biology of germline EGFR mutations have been hampered
… that patients with lung cancers found to harbor the EGFR T790M resistance mutation before …

… T790M mutation. Blue lesions indicate SCLC histology and none of the SCLC lesions had
the T790M mutation. … the adenocarcinoma component with a T790M mutation and the SCLC …

… The cobas plasma test detected the T790M mutation in 61% of tumor tissue T790M
mutation–positive patients. To mitigate the risk of false-negative plasma results, patients with a …

… In a randomized phase III study, osimertinib was superior to chemotherapy in EFGR-T790M …
mechanisms in the context of EGFR T790M-mutated lung cancer are now emerging in the …