… In the present study, we have examined the role of tachykinin NK2 receptors in the … stimulation
of colon afferents in normal rats and after the induction of acute colonic inflammation. The …

… NK 1 and NK 2 receptors) in rat colon in vitro were reduced by atropine but not by tetrodotoxin
suggesting the presence of facilitatory tachykinin receptors on cholinergic nerve terminals …

… intestinal inflammation or application of stressful stimuli to animals. Likewise, … rat colon can
be elicited through the selective stimulation of NK1 or NK2 receptors, although NK2 receptors …

… rectocolonic inflammation can be partially or totally reversed by the tachykinin NK2 receptor
… to jejunal distension), indicative of intestinal hyperalgesia was five times lower than needed …

… spontaneous colonic motility even in rats intrarectally treated with vehicle; this was done to
assess the effect of nepadutant on intestinal motility in the absence of inflammation. Colonic …

… antagonists (2628), tachykinin NKl and NK2 but not NK3 receptors seem to be … inflammation
in rats at the colonic level. Conversely, tachykinin NK2 and NK3 but not NKl receptors seem …

… Increased rat intestinal transit was selectively induced by a synthetic NK2 receptor agonist
… Administration in man of exogenous NKA by means of NK2 receptor stimulation was able to …

… NK2 receptors or these latter receptors predominantly, depending on the experimental
conditions. In contrast, in the human colonic smooth muscle, only the NK2 receptor-… rats. Neither …

… In conclusion, our study provides evidence that in the rat colon stimulation of tachykinin
NK 2 receptors leads to two independent responses; contraction (obtained in the muscularis …

… Nevertheless, a recent study in a rat model of colitis has shown that acute experimental
inflammation impedes COX-1 activity and that COX-2 becomes the predominant isoform in …