Neurokinin B‐ and specific tachykinin NK3 receptor agonists‐induced airway hyperresponsiveness in the guinea‐pig

S Daoui, E Naline, V Lagente… - British journal of …, 2000 - Wiley Online Library
Tachykinins induce … NK 3 receptor agonists to induce the development of airway
hyperresponsiveness. In the present study, we found that NKB and the tachykinin NK 3 receptor

Potency and selectivity of the tachykinin NK3 receptor antagonist SR 142801

JC Beaujouan, M Saffroy, Y Torrens… - European journal of …, 1997 - Elsevier
… Other authors have indicated that SR 48968 antagonizes the release of Ca 2+ from inositol
trisphosphate-sensitive intracellular stores evoked by tachykinin NK 3 receptor agonists in …

Molecular and pharmacological characterization of the murine tachykinin NK3 receptor

HM Sarau, JA Feild, RS Ames, JJ Foley… - European journal of …, 2001 - Elsevier
NK 3 receptors, respectively. Binding affinities and functional potencies of tachykinin receptor
agonists … ) 293 cells expressing murine NK 3 receptor and human NK 3 receptor, although …

Cardiovascular and behavioural effects of intracerebroventricularly administered tachykinin NK3 receptor antagonists in the conscious rat

E Cellier, L Barbot, D Regoli… - British journal of …, 1997 - Wiley Online Library
… Antagonist activities of SR142801 have been shown in various functional NK 3 receptor
agonist-evoked responses, notably the contraction of the guinea-pig ileum and of the rat portal …

Tachykinin neurokinin 3 receptor antagonists: a patent review (2005–2010)

P Malherbe, TM Ballard, H Ratni - Expert Opinion on Therapeutic …, 2011 - Taylor & Francis
… used to derive novel NK 3 receptor antagonists which have … agonist with the highest affinity
for the NK 3 receptor, binding … selective and potent agonist at the NK 3 receptor with a pK i …

Neurokinin-3 receptor antagonists

GAM Giardina, LF Raveglia - Expert Opinion on Therapeutic …, 1997 - Taylor & Francis
NK3 receptor agonists, a number of potential therapeutic indications for NK3 receptor
research explosion in the tachykinin area was mainly on NK1 and NK2 receptors, to a large …

GR138676, a novel peptidic tachykinin antagonist which is potent at NK3 receptors

JM Stables, IJM Beresford, S Arkinstall, SJ Ireland… - Neuropeptides, 1994 - Elsevier
… of tachykinin agonists, including the NK3 receptorpreferring … tachykinin antagonist, GR138676,
antagonised NK, receptor-… reported that tachykinin agonists bound to NK, receptors in …

The study of tachykinin receptors

E Burcher - Clinical and experimental pharmacology and …, 1989 - Wiley Online Library
… peripheral NK3 receptors have been described. In contrast, NKI, NK3 but not NK2 receptors
… A number of more selective peptide analogue agonists has been synthesised, for example, […

… tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor …

HM Sarau, DE Griswold, W Potts, JJ Foley… - … of Pharmacology and …, 1997 - ASPET
… of behavioral responses induced by the NK-3 receptor-selective agonist, senktide (ED 50 =
… and pathophysiological roles of NK-3 receptors. The mammalian tachykinins, also known as …

SCH 206272: a potent, orally active tachykinin NK1, NK2, and NK3 receptor antagonist

JC Anthes, RW Chapman, C Richard, S Eckel… - European journal of …, 2002 - Elsevier
… at human tachykinin NK 1 , NK 2 , and NK 3 receptors (K i =… cloned human tachykinin NK 1
, NK 2 , or NK 3 receptors. SCH … ±0.3) induced by the tachykinin NK 1 receptor agonist, [Met-O-…