… transplant protocol, tacrolimus dosing was titrated in the 19 kidney transplant recipients to
achieve tacrolimus trough levels of 8 to 10 ng/mL in the first month of transplantation. All 19 …

… 11 kidney transplant patients treated with tacrolimus and low-dose sirolimus, the patients had
good renal … To determine the optimal dose of sirolimus in combination with tacrolimus, we …

… kidney transplant recipients at 1, 3, and 6 mo post-transplant … of decrease on the tacrolimus
dose-adjusted trough levels. A … in the kidney transplant recipients, where the dose required …

… In this context, it should also be considered that changes in the therapeutic regimen (eg
antifungal therapy or changes in steroid doses leading to tacrolimus dose adjustments) can …

… (Kidney Disease Improving Global Outcomes) already suggested in 2009 that tacrolimus be
the first-line CNI used in kidney transplantation (KT) … In this study, the dose of tacrolimus was …

… Once a patient is maintained on a stable tacrolimus dose, fluctuations in tacrolimus levels
may reflect pharmacokinetic factors affecting drug absorption and metabolism, drug …

… However, as a potent CNI it has nephrotoxic potential leading to impaired renal … dose (C/D
ratio) is such a simple predictor. Therefore, we analyzed the impact of the C/D ratio on kidney …

… In 2005, nearly 70% of kidney transplant recipients received tacrolimus as a component
of the … are used to evaluate tacrolimus exposure and individualize tacrolimus dosing. …

… A randomised control trial in 196 children who had renal transplants has demonstrated
that tacrolimus was more effective than ciclosporin in preventing acute rejection after …

… explain up to 45% of the variability in Tc dose requirements ( 11 ). In agreement with several
… after kidney transplantation, that patients carrying the CYP3A5*1 allele had lower dose-…