… of adenine deaminase TadA-8e with a substituted type of catalytic substrate, which not
only eliminates intrinsic adenine … Because this unnatural cytosine deaminase-derived Td-CGBE …

… through introduction of TadA-8e and Rad51DBD We recently developed dual base editor
(A&C-BEmax) through fusion of adenine deaminase and cytosine deaminase with Cas9n 5 . …

… tadA/ecADAT2. Based on the following observations, we conclude that tadA is an adenosine
deaminase … (i) Recombinant tadA, purified to homogeneity, specifically deaminates tRNA …

… Additionally, reprogrammed TadA-8e variants enabled the … of TadA orthologs enabled the
generation of functional ABEs, CBEs, and ACBEs in this study, adenosine deaminases TadAs …

… In adenine base editing, the ABE (adenine base editor), which is composed of the evolved
tRNA adenosine deaminase … of Cas9n-fused TadA adenosine deaminase used for targeted …

… Notably, the adenosine deaminases TadA and Tad2p each have an … deaminases (CDAs)
(Supplementary Fig. 1 online) but dissimilar from that of other known adenosine deaminases. …

… TadA at a 1.8-Å resolution. This is the first structure of a deaminase acting on tRNA. A.
aeolicus … In this study, we solved the crystal structure of TadA from Aquifex aeolicus at a 1.8-Å …

… The adenine deamination activity of TadA-8e is 590 times that of TadA-7.10 (Richter et al.
2020). TadA-8e was developed from its parent deaminase TadA-7.10 by screening for …

… By contrast, the second TadA-8e domain does not … , TadA-8e–catalyzed cis-DNA deamination.
To explore this idea, we compared the kinetics of adenosine deamination by TadA-8e of a …

… adenosine deaminase (TadA) to generate TadA8r, which extends potent deoxyadenosine
deamination … TadA8.20 and TadA8e, the two most active TadA variants reported so far. ABE8r, …