The role of TAM family receptors in immune cell function: implications for cancer therapy

M Paolino, JM Penninger - Cancers, 2016 - mdpi.com
… Thus, modulation of TAM receptors has emerged as a potential … how TAM receptors control
immunity, with a particular focus on the regulation of anti-tumor responses and its implications

Ligand activation of TAM family receptors-implications for tumor biology and therapeutic response

V Davra, SG Kimani, D Calianese, RB Birge - Cancers, 2016 - mdpi.com
receptors, as well as novel strategies to target TAM ligands are being developed. This paper
will review the biology of TAM receptors … pursuit of TAM/Gas6 inhibitors in clinical practice. …

The role of TAM family receptors and ligands in the nervous system: from development to pathobiology

B Shafit-Zagardo, RC Gruber, JC DuBois - Pharmacology & therapeutics, 2018 - Elsevier
TAM receptors and their ligands in the nervous system. We highlight studies that explore the
function of TAM … , and multiple sclerosis (MS) using Gas6 −/− and TAM mutant mice models. …

Tam Receptor inhibition–implications for cancer and the immune system

P Aehnlich, RM Powell, MJW Peeters, A Rahbech… - Cancers, 2021 - mdpi.com
… interest and research into TAM inhibition. This … TAM receptor signaling in T cells and
natural killer (NK) cells. The aim of this review is to explore in detail the effects of TAM receptor

Biology of the TAM receptors

G Lemke - Cold Spring Harbor perspectives in biology, 2013 - cshperspectives.cshlp.org
The TAM receptors—Tyro3, Axl, and Mer—comprise a unique family of receptor tyrosine
kinases, in that as a group they play no essential role in embryonic development. Instead, they …

TAM receptor tyrosine kinases: biologic functions, signaling, and potential therapeutic targeting in human cancer

RMA Linger, AK Keating, HS Earp… - Advances in cancer …, 2008 - Elsevier
… Further research will be necessary to evaluate the full clinical implications of TAM family
The focus of this review is the TAM family which includes Tyro‐3, Axl, and Mer, three receptors

Immunobiology of the TAM receptors

G Lemke, CV Rothlin - Nature Reviews Immunology, 2008 - nature.com
… Prospects and implications Recent insights into TAM receptor function have many implications
for our understanding of innate immune regulation and the treatment of immune system …

TAM receptor signaling in development

T Burstyn-Cohen - The International journal of developmental biology, 2017 - ijdb.ehu.es
… -receptor interactions may elicit different molecular and cellular responses. Many of the TAM
… This review highlights current knowledge on the role of TAM receptors and their ligands …

TAM receptors in leukemia: expression, signaling, and therapeutic implications

L Brandão, J Migdall-Wilson… - Critical Reviews™ in …, 2011 - dl.begellhouse.com
… This review summarizes the role of TAM receptors in leukemia. We outline TAM receptor
delineate the signaling pathways downstream of receptor activation that have been implicated …

TAM-ing T cells in the tumor microenvironment: implications for TAM receptor targeting

MJW Peeters, A Rahbech, P thor Straten - Cancer Immunology …, 2020 - Springer
TAM receptors’ ambivalent functions on many different cell types therefore make therapeutic
TAM receptors in the tumor microenvironment. We place particular focus on TAM receptors