… Genetics, Women's and Children's Hospital, Adelaide 5006 Australia ABSTRACT The human
genome contains many repeated DNA … unit from a single nucleotide to a whole gene. The …

… human genetic disorder that lends support to the generality of tandem repeat-mediated
epigenetic changes in humans. … of the subtelomeric D4Z4 repeat array on chromosome 4. This …

… The repeat expansion diseases are a group of genetic disorders that … diseases can involve
a larger repeat unit [4]. Moreover, unstable tandem arrays with a wide range of repeat unit …

… and neuromuscular disorders, as well as complex genetic diseases like cancer and diabetes…
pathological correlation between TRs instability and human diseases. Finally, we provide a …

… tandem repeat biology, with a focus on the repeat-associated genetics and pathogenesis of
a range of human disorders. … disease-associated mutations involving repeat instability in the …

… centromere extends over several mega bases and contains both tandem repeats and
unique DNA sequences. Several centromere binding proteins (CENP-A through F) have been …

… Our method is robust to systematic sequencing errors, inexact repeats with … tandem repeats
in whole genome sequencing data. This may help to elucidate the many genetic diseases …

… we model tandem repeats by percent identity and … tandem repeats that have undergone
extensive mutational change by analyzing four sequences: the human frataxin gene, the human …

… role that such repeat elements play in gene function, elongation/… gene function which
eventually could lead to a disorder (Figure 1). At least 10 genetic disorders are known in humans in …

… information was downloaded from the Online Mendelian Inheritance in Man (OMIM)
database, which provides bibliographic, sequence and map information on genetic disorders, …