… tandem repeats, and these are widely dispersed and highly polymorphic. Members of one
group of the simple tandem repeats, the trinucleotide repeats, … In Huntington disease alleles of …

… repeat sizes for genetic loci, and we used this software to infer repeat sizes for 30 known
disease … We identified 138 individuals with risk alleles at 15 STR disease loci. We validated a …

… specific tandem repeat expansions can cause Huntington disease, … and other diseases; the
majority of these diseases are … smallest allele has n tandem repeats, then other alleles can …

… repeat expansion diseases are a group of human genetic disorders caused by long and highly
polymorphic tandem repeats. … on normal alleles are within 350 bp of the CGG-repeat tract. …

… ) in relatively long tandem repeats [15], but other types of length variations may … disease
risk. Here we focus on a class of very short tandem repeats and their contribution to disease risk. …

… In theory, for NRDs with this inheritance, the preferred principle would be to only target the
disease allele and not the normal allele. There are, however, arguments against this view. …

… First, they provide a framework in which to interpret the relevance of specific STR alleles
observed in disease contexts. Population-specific per-locus allele frequencies serve as a …

… , with a recent bioinformatics analysis suggesting that short tandem repeats occur more
frequently in disease-associated genes than those not known to be associated with disease [ …

… new mutation produces a new allele and all mutations are equiprobable. Therefore, it can
involve any number of tandem repeats and always results in a new allele state not previously …

… expansions within the top 10 out of 700,000 tandem repeats in whole genome sequencing
data. This may help to elucidate the many genetic diseases whose causes remain unknown. …