… targets that are involved in the pathogenesis of heart failure … This Review analyses the new
therapeutic targets (for … under development for the treatment of heart failure, and the possible …

… degradation of target mRNAs. Extant published work suggests that miRs are regulated
differentially in the failing heart and have a key role in pathogenesis of heart failure through their …

… heart failure. Numerous vasopressin antagonists are currently under development for the
treatment … antagonists on both normal physiology and heart failure were reviewed. RESULTS: …

… This list further increases our awareness as we begin to identify new metabolic targets for
the treatment of heart failure. A reasonable starting point would be to distinguish between …

… Target doses for heart failure compared with dose ranges used for hypertension for select
agents are listed in Table 1. In successful heart failure treatment trials with these agents, it has …

… in heart failure? Do other interventions known to improve endothelial function in heart failure
… would indeed represent an important therapeutic target in patients with chronic heart failure. …

… New therapeutic targets, agents, and strategies are needed to prevent and treat heart failure
(HF) … Improved left ventricular characterization permits the identification and targeting of the …

… (ECM) provide a potential therapeutic target for prevention of heart failure. This review focuses
on the therapeutic targeting of TGF-β in the prevention of pathological fibrosis in the heart. …

… heart failure with reduced ejection fraction. In acutely decompensated heart failure and heart
failure … reached on an optimal target heart rate in patients with atrial fibrillation and heart …

… The mechanisms of heart failure are complex and multiple, … on targeting mitochondrial
dysfunction in the failing heart to … areas for the development of heart failure therapies, including …