Targeting p38 MAPK pathway for the treatment of Alzheimer's disease

L Munoz, AJ Ammit - Neuropharmacology, 2010 - Elsevier
p38 MAPK inhibition and in vivo evaluation of p38 MAPK significance to various aspects of
AD pathology is still missing, the p38 MAPK … on the role of p38 MAPK in neurodegeneration, …

The p38 MAP kinase pathway as a therapeutic target in inflammatory disease

J Saklatvala - Current opinion in pharmacology, 2004 - Elsevier
… Inhibiting the MAPK pathway as an anti-inflammatory therapy might not … p38 MAPK itself;
targets upstream or downstream could also be blocked. As discussed below, the pathway is …

Novel strategies for inhibition of the p38 MAPK pathway

J Zhang, B Shen, A Lin - Trends in pharmacological sciences, 2007 - cell.com
… inhibitors and inhibitors that are targeted to other components of the signaling pathway. …
ATP to the protein targeted for phosphorylation. Many p38 target proteins are important kinases …

The p38 MAP kinase pathway and its biological function

L New, J Han - Trends in cardiovascular medicine, 1998 - Elsevier
… Thus, the p38 MAP kinase cascade may consist of the … other potential regulators of the
p38 pathway have been defined. … search of proteins targeted for phosphorylation by p38 and, …

Mechanisms and functions of p38 MAPK signalling

A Cuadrado, AR Nebreda - Biochemical journal, 2010 - portlandpress.com
MAPK families that usually function as parallel pathways in … provide an overview of the p38
MAPK pathway, which is strongly … based on targeted deletion of several p38 MAPK pathway

MAP kinase pathways activated by stress: the p38 MAPK pathway

T Obata, GE Brown, MB Yaffe - Critical care medicine, 2000 - journals.lww.com
… Direct substrates of p38 MAPK, as well as their downstream targets, are listed in Table 2.
Transcriptional control regions containing elements for both CREB and ATF1 are strongly …

p38 pathway kinases as anti-inflammatory drug targets

JF Schindler, JB Monahan… - Journal of dental …, 2007 - journals.sagepub.com
… Scientific exploration of this pathway from biological, cellular, and in vivo perspectives was …
inhibitors of p38 MAPK that target the α and β isoforms. p38 MAPK pathway function is critical …

[HTML][HTML] p38 signalling pathway

JJ Sanz-Ezquerro, A Cuenda - International Journal of Molecular …, 2021 - mdpi.com
… and obesity; they also discuss p38MAPK role in pathological conditions leading to type II
diabetes and the possibility of targeting these kinases in therapies for diabetes treatment [10]. …

[HTML][HTML] Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-κB ligand signaling

KC Mansky, U Sankar, J Han, MC Ostrowski - Journal of Biological …, 2002 - ASBMB
… -derived precursor cells blocked for p38 MAPK activity and the mi/… target of the p38 MAPK
in osteoclasts. In this study, we investigate whether MITF is a potential target of the p38 MAPK

[HTML][HTML] Activation and signaling of the p38 MAP kinase pathway

T Zarubin, J Han - Cell research, 2005 - nature.com
… or indirectly target proteins to control pre/post transcription. p38 MAPKs also have the ability
to activate other kinases and consequently regulate numerous cellular responses. Because …