Mechanisms of target organ damage caused by hypertension: therapeutic potential

G Cohuet, H Struijker-Boudier - Pharmacology & therapeutics, 2006 - Elsevier
… mortality and morbidity through its effects on target organs like the brain, heart, … target organ
damage. In this review, we describe damages related to hypertension in these target organs

Target organ damage: how to detect it and how to treat it?

B Waeber, A de la Sierra, LM Ruilope - Journal of Hypertension, 2009 - journals.lww.com
… the existence of subclinical target organ damage and other clinical conditions (diabetes,
established cardiovascular or renal disease) [5] . Target organ damage may represent not only …

Task force III: target-organ damage, morbidity and mortality

P Verdecchia, D Clement, R Fagard… - Blood Pressure …, 1999 - journals.lww.com
Objective: To reach a consensus on ambulatory blood pressure (ABP) as a predictor of
target-organ damage (TOD), morbidity and mortality. Method: The members of task force III wrote …

Early target organ damage and its reversibility: the heart

E Agabiti Rosei, ML Muiesan - Clinical and Experimental …, 2004 - Taylor & Francis
… In addition, blood pressure control may be difficult in hypertensive patients with target
organ damage, and may often require the use of antihypertensive agents in combination. …

Does obesity influence early target organ damage in hypertensive patients?

RE Schmieder, FH Messerli - Circulation, 1993 - Am Heart Assoc
… of obesity on early target organ damage in patients with essential … as parameters for early
target organ damage. All individuals were … Obesity had a disparate effect on target organs in …

[HTML][HTML] Pathogenesis of target organ damage in hypertension: role of mitochondrial oxidative stress

S Rubattu, B Pagliaro, G Pierelli… - International Journal of …, 2014 - mdpi.com
Hypertension causes target organ damage (TOD) that involves vasculature, heart, brain and
kidneys. Complex biochemical, hormonal and hemodynamic mechanisms are involved in …

Obesity and target organ damage: the kidney

PE De Jong, JC Verhave, SJ Pinto-Sietsma… - International Journal of …, 2002 - nature.com
Obesity is a risk marker for progressive renal function loss in patients with known renal
disease. There is, however, increasing evidence that obesity may also damage the kidney in …

[HTML][HTML] Resistant hypertension and target organ damage

ML Muiesan, M Salvetti, D Rizzoni, A Paini… - Hypertension …, 2013 - nature.com
… Resistant hypertension (RH) is associated with a higher risk of CV complications and a
higher prevalence of target organ damage (TOD). The relationship between CV disease and …

Kidney in diabetes: from organ damage target to therapeutic target

T Salvatore, O Carbonara, D Cozzolino… - Current Drug …, 2011 - ingentaconnect.com
Despite the growing of pharmacological options for the treatment of diabetes, epidemiological
studies suggest that a substantial proportion of patients does not achieve glycemic goals …

Obesity and target organ damage: the heart

H Schunkert - International Journal of Obesity, 2002 - nature.com
In most patients, coronary atherosclerosis or congestive heart failure develop as an integrated
response to multiple cardiovascular risk factors. Obesity increases the prevalence of most …