… cancer and AR + breast cancer xenograft models 90,91 . These preclinical findings suggest
that AR degradation may provide a potential therapeutic strategy … prostate cancer that small-…

… the desired degradation results. In this paper, we classify PROTACs according to E3 ligase
and summarize the PROTAC degradation strategies for different target proteins (Table 1). …

… molecules without affecting their protein levels. An emerging therapeutic strategy that
garnered attention in recent years is the induction of Targeted Protein Degradation (TPD) of …

… , extracellular proteins, and protein aggregates, thus greatly … a simple introduction of protein
degradation mechanisms. We … BTK is an established target in both inflammation and cancer…

… Targeted Protein Degradation (TPD) strategies have also been explored to target previously
undruggable proteins, … Targeting antiapoptotic proteins in cancer therapy has long been an …

… an efficacious therapeutic strategy, in particular for cancer, … chemical strategy for endogenous
target protein degradation. … -dependent posttranslational degradation with exquisite target-…

… technologies that achieve selective degradation of target proteins using heterobifunctional
small … and more attention because of its great potential in cancer treatment [17]. PROTAC is a …

… strategy translates the SERD mode of degradation into smallmolecule probes capable of
targeting various proteins for … drug target in prostate cancer, was selectively degraded using an …

… are already approved for treatment of cancer patients. The … of lysine residues in the target
protein, to form an isopeptide … inducing protein degradation (Figure 1), from targeted protein …

… Given these limitations, strategies have been developed for targeted protein reduction as
an alternative approach to cancer therapy. Targeted protein reduction may be readily …