… protein degradation to target proteins involved in different disease types. PROTACs have been
used to degrade proteins involved in various cancers… of a therapeutic strategy possessing …

… agent in cancer cells but also confined the targeted protein … PTT with targeted protein
degradation strategies is essential … modulation of targeted protein degradation through laser …

… studies and others suggest that targeting PKCδ and/or TG2 to induce autophagic cell death
may be a promising therapeutic strategy for the treatment of pancreatic cancer. In support of …

… Abstract: A novel strategy that targets protein for degradation … in effecting specific protein
degradation via the ubiquitin-… Firstly, MCF-7 breast cancer cells were treated with Protacs …

… a promising therapeutic window. In summary, TeloTACs represent an innovative DNA-based
targeted degradation strategy capable of shortening telomeres and impeding cancer cell …

… for the combination therapy of protein degradation and PDT in clinical cancer treatment. …
To explore the therapeutic efficiency of our proposed strategy on cancer, the 4T1 cells tumor…

… degradation of the target protein. Along with PROTAC, a protein degradation strategy using
the protein … In 2021, Novartis developed a BRD9 degrader for cancer treatment. BRD9 is a …

… , Proteolysis targeting chimeras (PROTACs) facilitate ubiquitination and degradation of the
… endows this strategy to degrade drug targets, especially useful for “undruggable” ones. …

… While targeted protein degradation is being actively explored for different conditions ranging
from cancers … Another strategy is to utilize bifunctional molecules with one end that binds the …

… the treatment of hormone-receptor positive breast cancer… strategy for monitoring high
throughput protein degradation has not yet manifested with methods varying for each target protein …