… pathway to accelerate degradation of specific cellular proteins. This article focuses on …
strategies successfully utilized recently for targeted degradation of specific cellular proteins …

… essential for tumour growth and survival may be the targets of protein degradation in
cancer… Targeting protein degradation in various cells and tissues can increase the therapeutic …

… tagging was employed to induce the degradation of the currently undruggable cancer
target … to induce targeted protein degradation has emerged as a viable therapeutic strategy. …

… Targeted protein degradation (TPD) is one of the key strategies of current targeted cancer
therapy, and it can eliminate some of the root causes of cancer, and effectively avoid drug …

… with these TPD strategies, aiming to provide insight into the targeting of dysregulated … ERβ
degradation in several types of cancer cells. As expected, MetAP2- and androgen receptor-…

… proof of concept for targeted protein degradation but has also … Two distinct classes of protein
degradation therapeutics are … landscape of targeted protein degradation approaches and …

… in Table 2, most of targets degraded by PROTACs are cancer-linked proteins such as AR,
ERα, BRD4 and BCR-ABL, implying a promising strategy for PROTACs in cancer therapy. …

… many degrader molecules, (2) greater target selectivity, even when starting with … target
upregulating feedback loops, and (4) the ability to address scaffolding functions of target proteins …

… Many traditional small molecule inhibitors have been exploited for cancer treatments [1-4], …
Phthalimide conjugation as a strategy for in vivo target protein degradation. Science, 2015, …

… of other strategies for the targeted protein degradation have … -based strategies, which open
the magic toolbox for protein … trials for the treatment of prostate cancer and breast cancer, …