… and research in the treatment of different diseases, such as cancer, cardiovascular … strategy
to develop drugs relying on the UPS system for targeted protein degradation for NDs therapy…

… for intracellular protein degradation but also offer unique strategies for targeting pathologic
proteins … of inducing targeted degradation of secreted proteins relevant to cancer metastasis. …

… chemoproteomic profiling of the binding proteins in triple-negative breast cancer cells. The
E3 … in translating the targeted protein degradation strategy into practical clinical applications. …

… many degrader molecules, (2) greater target selectivity, even when starting with … target
upregulating feedback loops, and (4) the ability to address scaffolding functions of target proteins …

… , targeted protein degradation (TPD) has surfaced as a novel and innovative chemical tool
and therapeutic … Lastly, we discuss the future of TPD and its potential as a therapeutic strategy. …

… targeted protein degradation (TPD) strategies, which are different from the traditional therapeutic
… release over PROTAC and synergistic cancer treatment. Reproduced with permission. …

… proteins with overlapping functionality. A robust network paradigm has critical implications
for targeted cancer therapies, predicting that in cells treated with … of distinct proteins that are …

… degradation of target proteins to regulate the protein level. As a new drug development strategy,
its … molecules induced degradation of BTK, CDK4/6, BCR-ABL and BRAF in cancer cells …

… including resiliency to acquired mutations in the target protein, … proteins. Herein, we review
the development of proteolysis targeting chimeras (PROTACs) for selected cancer therapy …

… protein degradation that lead to cellular apoptosis. The current review focuses on targeted
protein degradation and its use in the treatment … strategy used for targeted protein degradation …