… protein degradation systems. This review highlights the most recent advances in targeted
protein … degradation (TPD) are emerging strategies which aim to achieve loss of function and …

… targeted proteins is an emerging therapeutic strategy, noted for its high selectivity and efficiency
of protein degradation. [ 1, … the bioavailability of PROTACs for cancer treatment. [ 22-24 ] …

… in targeting TF proteins. For this reason, technologies that enable targeted protein degradation,
such as proteolysis-targeting … Currently, the main inhibition strategy for c-MYC focuses on …

… novel therapeutic strategies that simultaneously target both pathways, aiming to improve …
This makes the protein degradation pathway a potential target for treating cancer [4]. This …

… disease-relevant proteins via a therapeutic strategy termed targeted protein degradation (TPD). …
, a membrane-associated protein that plays a significant role in cancer cell proliferation. …

… Targeted protein degradation (TPD) strategies open up new … heat shock protein 90 (HSP90)–mediated
targeting chimeras … relationship between HSP90 and cancer, as described here, …

… Crucially, the iRGD modification strategy offers remarkable advantages in the … of targeted
protein degradation therapeutics. Our future endeavors will focus on exploring diverse targeting …

… action underpinning targeted protein degradation strategies, including proteolysis-targeting …
in tumors, a factor that severely limits the clinical utility of existing targeted cancer therapies. …

… of the kinase activity, is a strategy with the potential to yield a … can be accomplished using
Proteolysis targeting chimeras (… Given their well-defined role in human cancers and the broad …

… The evolution of cancer treatment has provided increasingly targeted strategies both in the
upfront and relapsed disease settings. Small-molecule inhibitors and immunotherapy have …