… the target, marking it for proteasomal degradation. This … the wider field of targeted protein
degradation have expanded … as chemical tools to study proteins and as drug candidates …

… crucial role in the degradation of protein aggregates, misfolded proteins, lipid droplets…
Targeted protein degradation via lysosomal pathways. LYTACs consist of two parts: one for protein …

… Ubiquitination regulates protein degradation [PMID:… a target protein or protein complex using
a speci c antibody followed by mass spectrometry analysis to identify the interacting proteins…

… Over the last two decades, proteolysis targeting chimeras (PROTACs) have been
revolutionary in drug development rendering targeted protein degradation (TPD) as an emerging …

… Targeted protein degradation is a pharmacological modality based on the induced proximity
… and a target protein to promote target ubiquitination and proteasomal degradation. This has …

… This book is intended as a beginner’s guide to microbes and enzymes and how to use
them to do synthetic organic reactions in the laboratory. Rather than a list of reactions, or an …

… these pathways involve proteins that could constitute targets for NF-κB inhibition. Several
inhibitors aiming to prevent NF-κB activity and thus the transcription of target genes are studied…

… This is required for hydrolysis and transfer of phosphate onto specific surface residues on
target proteins. Protein kinases are a large family of proteins, which catalyze this reaction as a …

… It is important to keep in mind that guide designs must be optimized to reduce off-target
binding and cleavage. There are many tools available for guide design that predict the on-target …

… A Beginner's Guide to Microarrays addresses two audiences-the core facility manager
who produces, hybridizes, and scans arrays, and the basic research scientist who will be …