… interesting drug targets. However, the druggability of these newly identified target proteins
is … of target identification. For the past 20 years, drug development has almost exclusively …

Targeted protein degradation as a therapeutic modality has seen dramatic progress and
massive investment in recent years because of the convergence of two key scientific …

… Targeted Protein Degradation (TPD) strategies have also been explored to target previously
undruggable proteins… of the proteins targeted by PROTACs and the biological effects of their …

… In this special issue, we aim to highlight a few of the key advances in the field of targeted
protein degradation. The 15 review articles included within this issue highlight the …

… The ssrA tag targets proteins for degradation by several proteases 90 . Most other bacterial
… -independent, so this method does not require ubiquitination for target protein degradation. …

… , and the E3 ubiquitin-protein ligase, the last of which delivers multiple ubiquitin molecules
to the target protein. The resulting polyubiquitin chain formed on the target protein, in turn, …

… activity of functional protein domains. In contrast, targeted protein degradation aims to
reduce overall levels of disease-relevant proteins. Mechanistically, this can be achieved via …

… Typically, multiple ubiquitin (Ub) units are attached to a lysine residue on the target protein
via the sequential action of a three-enzyme cascade: a ubiquitin-activating enzyme (E1), a …

… (TPD) technologies have attempted to revolutionize the fields of chemical biology and …
system to mediate target protein degradation. This then limits protein targets to cytosolic domains …

… cellular quality control machinery to target proteins for degradation. Bauer and colleagues
… target proteins to the lysosome for degradation. One study targeted mutant huntingtin protein …