… protein for degradation through the endogenous cell machinery. In the present review,
we focus primarily on tools for conditional control of protein … protein degradation. The GFP-tagged …

… decades, there has been growing interest in the field of targeted-protein degradation (TPD), …
TPD strategies have largely focused on bringing together a eukaryotic, intracellular protein …

… for targeting proteins, thereby expanding the scope of TPD platforms to include secreted …
Professor Laura MK Dassama is a chemical and structural biologist who uses tools of chemistry …

… proteins, the current strategies are static in nature and lack the ability to modulate protein
degradation … Here, we introduce a synthetic framework for dynamic fine-tuning of target protein …

… synthetic biology toolkits for conditional and targeted protein degradation in mammalian
systems… site of E2 to a lysine on the target or growing polyubiquitin chain. RING E3s catalyze the …

… Adding to the proteolyis targeting chimera (… of proteins involved in various human diseases.
Firstly, we describe the key protein/macromolecular complexes and various degradation…

… Herein, we review the wide and expanding use of thalidomide … With novel degrader drugs
poised to expand the druggable … development of targeted protein degradation platforms. …

… basic research, while providing a novel toolkit for applied life science such as biotechnology
… the manipulation of target proteins, further expanding the scope and toolbox of TPD. …

… 2015, targeted protein … Targeted Protein Degradation is a timely guide to navigating the
complexities of the subject and understanding its practical application, with an eye on expanding …

… unfolded proteins to induce target protein degradation, … are not just useful chemical tools
but also viable therapeutic … a step towards expanding the range of targets for this approach. …