… Targeted protein degradation has created tremendous excitement in chemical biology and
… targeted protein degradation and discusses them from a medicinal chemist's perspective. …

… Targeted protein degradation (TPD), via the proteasomal and lysosomal pathways,
represent a novel tool to explore cellular pathways and a promising therapeutic approach. The …

… However, recent advancements in the medicinal chemistry and chemical biology fields have
contributed significantly to change the traditional view of targeting such proteins. Since 2012…

… of degradation of one or more member proteins can lead to a … targeted protein degradation
field with respect to selectivity. … From our perspective, some of the key biological attributes to …

… There are many opportunities for pharmacological intervention with protein degradation
catalyzed by proteasomes. Proteasome inhibitors are potential drugs for treating several …

… glue technology are the hotspot applied to targeted protein degradation (TPD) using UPS in
recent … have taken a different approach, using the UPS to prevent target proteins from being …

… foundational modalities for targeted protein degradation. Left-… perspective offers the first
comprehensive assessment of future potential targets with an eye towards protein degradation …

… If the two lead compounds do not have similar structures or the binding regions of the two
target proteins are not similar, the merged-pharmacophore strategy is difficult to implement. …

… selectivity, eg, the drug target must be exclusively or preferentially expressed … , targeted
proteins in a pathogen should not have homologous proteins in the host or homologous proteins …

… target identification methods have been used to successfully elucidate the target proteins
of … that display weak affinity to the target (the KTGS approach) is considered a robust way to …