… Antiphospholipid (aPL) antibodies (Abs) are associated with thrombosis and pregnancy loss
in antiphospholipid syndrome … triggered by aPL Abs on target cells in coagulation pathways …

… modalities of targeted therapies for … therapeutic approaches to APS. In this article, we review
the pathophysiological mechanisms of thrombosis and the specific new targeted therapies …

Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterized by thrombosis
and/or pregnancy morbidity with persistent levels of antiphospholipid … are not targeted …

… recent clinical studies with other targeted therapies discussed below have been … targeted
therapies to background immunosuppression with MMF may become an effective therapeutic …

… , and evaluate targeted therapies against endothelial dysfunction-mediated APS thrombophilia
and vasculopathy. A paradigm shift aimed at investigating new therapeutic targets is of …

… pathogenic antiphospholipid antibodies (… therapeutic targets that are currently being
explored for APS in order to address the unmet needs of better, safer and ideally targeted therapy. …

… -mediated vascular abnormalities and is a potential new therapeutic target to be aimed at. …
glycoprotein I as a novel therapy for antiphospholipid syndrome. Blood. 2014;123:3478–87. …

… therapies targeting these mechanisms. In this section, we will focus on the evidence for these
potential, targeted … and peptide therapy. A summary of key points is provided in Table 1. …

… The effectiveness of high-intensity anticoagulation in patients with antiphospholipid syndrome
(APS) … , and other targeted therapies that have been effective in experimental APS models. …

Antiphospholipid syndrome is an autoimmune disease characterized by thrombosis and
pregnancy morbidity occurring in patients persistently positive for aPL. Current therapeutic …