… In particular, vascular endothelial growth factors (VEGFs) … -A, B, C, D and placental growth
factor (PIGF)] are encoded by … the continuous stimulation of growth factors at the cell surface …

… two most advanced mAbs targeting the extracellular domain … Second class of agents targeting
EGFR are TKIs which have … and vascular endothelial growth factor receptor inhibitors are …

… The tenet of this review is that there are additional mechanisms in the case of particular
growth factors and cytokines by which signals can reach the nucleus, whereby internalized …

… Epidermal growth factor receptor (ErbB1, EGFR) is overexpressed in a variety of human … as
a rational target for drug delivery. To identify novel ligands with specific binding capabilities to …

… Unlike normal melanocytes, primary and metastatic human melanomas express high
levels of basic fibroblast growth factor (bFGF) and fibroblast growth factor receptor-1 (FGFR-1) …

… targeting the insulin-like growth factor receptor type 1 (IGF-1R) is in an advanced stage of
clinical development. The choice of this receptor tyrosine kinase (RTK) as a target … growth and …

… Here we review three major strategies to develop new ErbB-targeted therapies. These are
monoclonal anti-receptor antibodies, specific tyrosine kinase inhibitors and antagonists of …

… (1) The genes encoding the ligands insulin-like growth factor-1 and -2 (IGF1, IGF2) as well
… , and the possibility of therapeutically targeting cellular signaling mediated by the receptor …

… fgf-15 was identified as a downstream target of E2A-Pbx1, a homeodomain transcription
factor fused by the t(1;19) chromosomal translocation in pre-B cell leukemias to the activation …

… Like its predecessor, hormonal therapy, targeted therapy … Although their targets differ,
responses to targeted drugs are … What follows is a concise description of targeted therapies …