… The stabilizing role of properdin on the alternative pathway C3 convertase means that
blocking this positive regulator may be therapeutic in inflammatory disease. A mAb targeting …

… Importantly, such roles illustrate why therapeutic targeting of IL-6 family members has been
often associated with clinical benefit in inflammatory diseases, where these processes are …

… whether targeting this axis is a promising therapeutic strategy or not. Further studies are
needed to better understand which molecule to target and which relevant therapeutic tool we …

… Thus, the use of anti-inflammatory agents, either alone or in combination with cytotoxic
agents and targeted therapies, is an appealing strategy for the treatment of inflammation-driven …

… As a consequence of its involvement in multiple stages of the immune-inflammatory … of
immunemediated inflammatory diseases affecting multiple organ systems. Diseases in which a …

… inflammatory diseases, thus representing a new class of promising agents for treating
inflammatory diseases… for cancer therapy and for potential treatment of inflammatory diseases, and …

… approaches to specifically target individual PHDs or … or approaches to specifically target
intestinal epithelial cells). … of inflammation during acute or chronic inflammatory disease …

… and clinical trials of MSCs and MSC-Exos in various inflammatory diseases in detail, with
a view to contributing to the treatment of MSCs and MSC-Exos in inflammatory diseases. …

… of IME-targeted nanotherapies for inflammatory diseases. The development of rational
targeting … tailored to IMEs in damaged tissues can help promote therapies for chronic diseases. …

… of preclinical HMGB1-targeted therapy studies in multiple inflammatory conditions and …
opportunity to ameliorate systemic inflammatory diseases. Therapeutic interventions to regulate …