The renin-angiotensin-aldosterone system is one of the most … Therefore, it is already a very
successful drug target for the therapy … Other tissue renin-angiotensin-aldosterone systems are …

… major target for therapeutic interventions in these conditions. E-mail: [email protected] …
renin-angiotensin system (RAS) activity may represent an ideal target for pharmaceutical treatment …

The role of the renin-angiotensin system (RAS) in the development of various malignancies
has recently been extensively examined and, since it has been shown to significantly …

… central target in clinical hypertension therapy. Renin, a protein synthesised by the juxtaglomerular
cells of the kidney, cleaves the polypeptide angiotensinogen to generate angiotensin I …

… We review existent medications for RASi therapy and show research on novel drugs, including
small molecules and nanodelivery strategies that can target the brain RAS with potential …

… treatment, this rise in angiotensin I will lead to a similar rise in angiotensin II, whereas during
ACEi, the rise in angiotensin … Depending on the degree of ACEi, angiotensin II levels may …

… Thus, angiotensin II is an excellent target for pharmacologic blockade. Not only does it play
a pivotal role in both the acute and chronic regulation of systemic arterial pressure, but it also …

… of blood pressure and determinant of target-organ damage from hypertension is the renin–…
in the renin–angiotensin–aldosterone cascade have been the targets for pharmacological …

… (RAAS) is already the most important target for drugs in the … the two major RAAS effector
hormones, angiotensin (Ang) II and … targets have been identified in RAAS, such as the (pro)renin …

… Results obtained with this approach may direct investigators to explore additional therapeutic
targets in the future, such as other angiotensin receptor subtypes, other relatively specific …