… We have previously shown that the HIV-1 Tat protein can associate with PKR in vitro and in
… Tat can inhibit PKR activity by both RNA-dependent and RNA-independent mechanisms. …

… independent from the viral Tat protein, arguing against the possibility that removal of the …
protein BRD4, which functions as a cellular competitor for Tat, serves as a primary mechanism …

… Because HIV-1 Tat possesses the same functional domains that lead to increased … bound
virus and cells, we hypothesized that Tat could enhance gene transfer by a similar mechanism. …

… transduction domain (PTD) was derived from amino acids 47–57 of the HIV TAT protein after
it was shown that full length Tat protein could be taken up by cells and activate transcription …

… More recently, an active mechanism based on … the mechanism of entry is dependent on
the cargo connected to the CPP, we directly compared TAT fused to globular proteins and TAT-…

… In the late eighties, the recombinant HIV-1 Tat protein was … Tat derived peptide was chemically
bound to entire proteins … translocating property of the Tat protein was later reduced down …

… indicate that NF-κB plays a key role in Tat-dependent microglial activation, and that
oxidative stress and NF-κB activation induced by Tat occur by independent mechanisms. …

… The Tat protein of human immunodeficiency virus type 1 (HIV-1) is essential for productive …
demonstrate TAR-independent transactivation of HIV-1 transcription by the Tat protein in a cell…

… from possessing a pore-forming role, suggesting another mechanism of Tat translocation
whereby TatABC contributes the bulk of the translocation … The Tat protein export pathway …

… transport is currently unstudied, it is probably fair to assume that ironsulphur clusters are
assembled and inserted into Tat substrates by the same mechanisms as their cytoplasmic …