… present study was on Tat 1-72 -mediated induction of inflammatory mediators. However, …
in Tat 1-72 -injected brains have been made. Specifically, integrin-αM labeling revealed that Tat …

… protein was markedly overexpressed on brain vascular endothelium. These data indicate that
Tat 1−72 can induce redox-related inflammatory … of soluble mediators, such as Tat protein, …

… estrogen may attenuate the HIV Tat protein-induced inflammatory pathways in human vascular
endothelium. Methods: Expression of inflammatory mediators in human endothelial cells …

… is sufficient for transcriptional activation of both the TNFO and HIV-1 promoters (68), suggesting
that similar mechanisms may mediate cellular and viral gene expression by Tat. TNFj3 …

… to be induced on KS cells by inflammatory mediators such as poly(I:C), IL-1β and TNFα [ 5,49
]. Flow cytometry was performed to determine if Tat protein could also induce cell adhesion …

… In summary, we have shown that transduced Tat-ATOX1 markedly suppressed inflammatory
… -inflammatory mediator proteins, as well as activated NF-κB and MAPK, suggesting that Tat-…

… induction of brain inflammatory mediators in response to HIV-1 Tat protein. Such alterations
may play an important role in the development of brain inflammatory reactions in HIV-…

… Treatment of primary monocytes with soluble HIV-Tat protein is associated with
increased … We next examined the possible role of these cytokines as the mediators of HIV-Tat-induced …

… secretion and entry into uninfected T cells is advantageous for the virus, providing evidence
that Tat is a virulence factor and not solely a mediator of viral transcription. This finding …

… Together, these data indicate that NFκB and MAPK mediate distinct aspects of Tat-mediated …
that Tat can activate multiple inflammatory pathways in N9 microglial cells. Specifically, Tat …