HIV-1 Tat protein upregulates inflammatory mediators and induces monocyte invasion into the brain

H Pu, J Tian, G Flora, YW Lee, A Nath, B Hennig… - Molecular and Cellular …, 2003 - Elsevier
… , such as Tat protein, may play critical roles in the progression of this disease. Tat has been
… study was performed on recombinant Tat protein derived from the first exon, ie, Tat 1-72 . …

HIV-1-Tat protein promotes chemotaxis and invasive behavior by monocytes.

RM Lafrenie, LM Wahl, JS Epstein… - … (Baltimore, Md.: 1950 …, 1996 - journals.aai.org
… In the present study, we have directly examined the role of HIV-Tat in monocyte chemotaxis
and in the promotion of monocyte invasion through extracellular matrix-coated filters. …

HIV-1 Tat promotes monocyte chemoattractant protein-1 secretion followed by transmigration of monocytes

IW Park, JF Wang, JE Groopman - Blood, The Journal of the …, 2001 - ashpublications.org
… , such as the induction of endothelial cell growth, migration, and invasion in vitro.24 To …
Thus, we examined whether these surface molecules are activated by Tat protein. To this …

HIV-Tat dependent chemotaxis and invasion, key aspects of tat mediated pathogenesis

R Vene, R Benelli, DM Noonan, A Albini - Clinical & experimental …, 2000 - Springer
… We have also found that Tat is able to mimic chemokines, activating monocyte migration …
Tat protein acts as an angiogenic factor and was shown to induce the migration and invasion of …

Monocyte-derived dendritic cells and monocytes migrate to HIV-Tat RGD and basic peptides

R Benelli, R Mortarini, A Anichini, D Giunciuglio… - Aids, 1998 - journals.lww.com
Tat peptides contribute to dendritic and monocyte cell migration. In vivo, Tat stimulates invasion
… RANTES and macrophage chemotactic protein (MCP)-1 in inducing monocyte migration. …

[HTML][HTML] Identification of a novel domain of HIV tat involved in monocyte chemotaxis

A Albini, R Benelli, D Giunciuglio, T Cai… - Journal of Biological …, 1998 - ASBMB
Tat is released to enhance monocyte chemotaxis. A series of overlapping peptides was used
to scan for monocyte … recombinant or synthetic Tat proteins are chemotactic for monocytes ( …

[HTML][HTML] HIV tat-mediated induction of monocyte transmigration across the blood–brain barrier: Role of chemokine receptor CXCR3

F Niu, K Liao, G Hu, S Moidunny, S Roy… - Frontiers in cell and …, 2021 - frontiersin.org
… peripheral monocytes is known to play a role in the monocyte influx … monocytes to HIV Tat
protein resulted in upregulated expression of CXCR3 leading, in turn, to increased monocyte

HIV-1-Tat modulates the function of monocytes and alters their interactions with microvessel endothelial cells. A mechanism of HIV pathogenesis.

RM Lafrenie, LM Wahl, JS Epstein… - … (Baltimore, Md.: 1950 …, 1996 - journals.aai.org
… Treatment of primary monocytes with soluble HIV-Tat protein mimicked many of the … tissue
invasion by both infected and uninfected monocytes and by enhancing local release of MMPs. …

… virus transactivator protein (Tat) stimulates chemotaxis, calcium mobilization, and activation of human polymorphonuclear leukocytes: implications for Tat-mediated …

R Benelli, A Barbero, S Ferrini, P Scapini… - The Journal of …, 2000 - academic.oup.com
monocyte migration. Here it is shown that polymorphonuclear leukocytes (PMNL), mostly
neutrophils, rapidly invade in response to TatTat to PMNL chemotaxis, we tested 2 Tat proteins

Monocytes Treated with Human Immunodeficiency Virus Tat Kill Uninfected CD4+ Cells by a Tumor Necrosis Factor-Related Apoptosis-Induced Ligand-Mediated …

Y Yang, I Tikhonov, TJ Ruckwardt, M Djavani… - Journal of …, 2003 - Am Soc Microbiol
… , and promotion of microvascular invasion (19). We demonstrated that TRAIL expression
by … Here we show that after stimulation with HIV Tat protein, human monocytes upregulate …