[HTML][HTML] Tau pathology in Alzheimer disease and other tauopathies
… In conclusion, tau pathology appears to be both … diseases, tau pathology is seen in the
form of the abnormally hyperphosphorylated protein. The abnormal hyperphosphorylation of tau …
form of the abnormally hyperphosphorylated protein. The abnormal hyperphosphorylation of tau …
[HTML][HTML] Propagation of tau pathology in a model of early Alzheimer's disease
A De Calignon, M Polydoro, M Suárez-Calvet… - Neuron, 2012 - cell.com
… with histological stains of tau pathology (Figures 3A–3C ; also see Table S1). We find that
neurons in the granular layer of the DG developed tau pathology several months after lesions …
neurons in the granular layer of the DG developed tau pathology several months after lesions …
Relationship between tau pathology and neuroinflammation in Alzheimer's disease
MJ Metcalfe… - Mount Sinai Journal of …, 2010 - Wiley Online Library
… of Alzheimer’s disease. In this review, we focus on the pathological properties of tau thought
… a critical contributor to the pathology of Alzheimer’s disease. A better understanding of the …
… a critical contributor to the pathology of Alzheimer’s disease. A better understanding of the …
Tau pathology and neurodegeneration contribute to cognitive impairment in Alzheimer's disease
… between tau pathology and cognitive impairment across the Alzheimer’s disease spectrum.
However, tau pathology is also intimately associated with neurodegeneration and amyloid …
However, tau pathology is also intimately associated with neurodegeneration and amyloid …
[HTML][HTML] PET imaging of tau pathology in Alzheimer's disease and tauopathies
OG James, PM Doraiswamy, S Borges-Neto - Frontiers in neurology, 2015 - frontiersin.org
… tau (non-target) binding to other CNS receptors and tissues (eg, white matter) (12–15). To our
knowledge, at least seven tau pathology … desired specific affinity to tau tangles. For instance…
knowledge, at least seven tau pathology … desired specific affinity to tau tangles. For instance…
Tau protein pathology in Alzheimer's disease and related disorders
Tolnay, Probst - Neuropathology and applied neurobiology, 1999 - Wiley Online Library
… disorders with tau pathology definite diagnosis still needs neuropathological examination. …
We have recently shown that there is a marked neuritic tau pathology in PD [ 86]. …
We have recently shown that there is a marked neuritic tau pathology in PD [ 86]. …
Hypothesis: Tau pathology is an initiating factor in sporadic Alzheimer's disease
AFT Arnsten, D Datta, K Del Tredici… - Alzheimer's & …, 2021 - Wiley Online Library
… sporadic Alzheimer's disease (sAD) may have differing origins. We propose that tau pathology
… non-human primate models, where the earliest stages of tau pathology can be captured. …
… non-human primate models, where the earliest stages of tau pathology can be captured. …
Tau in Alzheimer's disease
EM Mandelkow, E Mandelkow - Trends in cell biology, 1998 - cell.com
… in the gene encoding tau. This article discusses how changes in tau protein could lead to
retraction of neuronal processes and thus cell death and argues that tau pathology, rather than …
retraction of neuronal processes and thus cell death and argues that tau pathology, rather than …
Tau pathology and neurodegeneration
MG Spillantini, M Goedert - The Lancet Neurology, 2013 - thelancet.com
… (C) Neuritic plaques made of amyloid β (blue), and neurofibrillary tangles and neuropil
threads made of tau (brown) in Alzheimer's disease. Immunohistochemistry with anti-…
threads made of tau (brown) in Alzheimer's disease. Immunohistochemistry with anti-…
[HTML][HTML] Propagation of tau pathology in Alzheimer's disease: identification of novel therapeutic targets
AM Pooler, M Polydoro, S Wegmann… - Alzheimer's research & …, 2013 - Springer
… In this review, we discuss the evidence for regulated tau release and its specific uptake by …
of tau pathology, as inhibition of tau transfer may restrict development of tau tangles in a small …
of tau pathology, as inhibition of tau transfer may restrict development of tau tangles in a small …
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