… Tax failed to transform primary human T lymphocytes. We conclude that Tax is essential
for HTLV-mediated transformation of human T lymphocytes. Furthermore, this chimeric HTLV, …

… , which encodes a T-cell-specific tyrosine kinase (45). Constitutive … T cell lines (R.
Perlmutter, personal communication); however, as with T3, our findings suggest that the tax gene …

… Together, these capacities render Tax highly oncogenic as reflected by its ability to … human
T-cells and to induce tumors in transgenic mice. In this article we discuss these effects of Tax …

… be required to produce tumors of NIH 3T3 cells by Tax, the tumorigenicity ofTax might be …
as in Rat-1 cells coincide upon immortalized T cells. The transgenic mice with tax gene develop …

… Furthermore, we examined IL-15Rα mRNA levels in T cells from normal donors vs T cells
from patients with ATL (Fig. 1 B). Following normalization for loading based on GAPDH levels (…

… It is this activity of Tax that has been postulated to lead to the proliferation and transformation
of T cells in ATLL (7-9). Additional support for the role of Tax in leukemogenesis comes …

… Tax also interacts with Cdk4 and Cdk6 and increases their activities in primary human T
cells (65). Tax has also been shown to interact with and inactivate the Cdk inhibitor p16INK4a (…

… immunodeficiency virus type I enhancer by the human T-cell leukemia virus type I tax gene …
of T cell-derived lymphokine genes in T cells and fibroblasts: effects of human T cell leukemia …

… fluid, CD8+ cytotoxic T lymphocytes are primarily reactive to the product of the HTLV-I tax
gene, we sought evidence of expression of this gene within cells in the inflammatory lesions. …

… the frequency of Tax 11-19 -specific CD8+ T cells and the percentage of CD4+ T cells in …
mechanism that persistently destroys Tax-expressing HTLV-I-infected CD4+ T cells in vivo. …