… Tax-mediated transformation and leukemogenesis. This review will concentrate on the effects
of Tax … as well as the suppression of DNA damage repair leading to cellular transformation. …

… The HTLV Tax protein is crucial for viral replication and for … transformation leading to the
development of adult T-cell leukemia. Tax has been shown to be oncogenic, since it transforms …

… Accordingly, one perspective is that transformation occurs when both gatekeeper and caretaker
… on how Tax perturbs normal cellular regulation and engenders cellular transformation. …

… Tax, other HTLV-I proteins have been shown to affect cell cycle and DNA repair and may
cooperate with Tax's effects in the transformation … RNA form to support T-cell proliferation [89]. …

… for the transformation of rat cell lines by Tax. Although the cellular genes responsible for
the transformation of REF by Tax remain to be determined, they are activated by Tax via the …

… The transforming activity of Tax identified in the present study is not apparently related to
the … transformation system was based on the already established rodent fibroblast cell lines. …

… Tax failed to transform primary human T lymphocytes. We conclude that Tax is essential for
HTLV-mediated transformation of … replicates in the absence of Tax, should facilitate studies to …

… cellular genes, and can transform rat fibroblasts. To determine the functional importance of
its trans-acting capacities in cell transformation… -by mutational analysis of Tax.In contrast to a …

… comprehensive list of cellular genes regulated by the HTLV-I Tax protein and have
highlighted a subset of these genes for discussion of their potential effects on cellular transformation. …

… of the HTLV-1 virus Tax protein in cellular death and transformation. For 30 years, Tax has
been at the center of HTLV-1 research and there is no doubt that Tax is a critical factor for …